The myriad roles of cyclic AMP in microbial pathogens: from signal to sword
KA McDonough, A Rodriguez - Nature Reviews Microbiology, 2012 - nature.com
All organisms must sense and respond to their external environments, and this signal
transduction often involves second messengers such as cyclic nucleotides. One such …
transduction often involves second messengers such as cyclic nucleotides. One such …
[HTML][HTML] A scoping review of intermittent fasting, chronobiology, and metabolism
Chronobiology plays a crucial role in modulating many physiologic systems in which there is
nutritional synergism with meal timing. Given that intermittent fasting (IF) has grown as a …
nutritional synergism with meal timing. Given that intermittent fasting (IF) has grown as a …
Translocation of sickle cell erythrocyte microRNAs into Plasmodium falciparum inhibits parasite translation and contributes to malaria resistance
Erythrocytes carrying a variant hemoglobin allele (HbS), which causes sickle cell disease
and resists infection by the malaria parasite Plasmodium falciparum. The molecular basis of …
and resists infection by the malaria parasite Plasmodium falciparum. The molecular basis of …
PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum
Abstract Calcium Dependent Protein Kinases are key effectors of calcium signaling in
malaria parasite. PfCDPK1 is critical for asexual development of Plasmodium falciparum, but …
malaria parasite. PfCDPK1 is critical for asexual development of Plasmodium falciparum, but …
Targeting malaria parasite invasion of red blood cells as an antimalarial strategy
AL Burns, MG Dans, JM Balbin… - FEMS microbiology …, 2019 - academic.oup.com
Plasmodium spp. parasites that cause malaria disease remain a significant global-health
burden. With the spread of parasites resistant to artemisinin combination therapies in …
burden. With the spread of parasites resistant to artemisinin combination therapies in …
Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery
A Patel, AJ Perrin, HR Flynn, C Bisson… - PLoS …, 2019 - journals.plos.org
Cyclic AMP (cAMP) is an important signalling molecule across evolution, but its role in
malaria parasites is poorly understood. We have investigated the role of cAMP in asexual …
malaria parasites is poorly understood. We have investigated the role of cAMP in asexual …
Protein kinases of malaria parasites: an update
Protein kinases (PKs) play crucial roles in the control of proliferation and differentiation in
eukaryotic cells. Research on protein phosphorylation has expanded tremendously in the …
eukaryotic cells. Research on protein phosphorylation has expanded tremendously in the …
Host and symbiont cell cycle coordination is mediated by symbiotic state, nutrition, and partner identity in a model cnidarian-dinoflagellate symbiosis
The cell cycle is a critical component of cellular proliferation, differentiation, and response to
stress, yet its role in the regulation of intracellular symbioses is not well understood. To …
stress, yet its role in the regulation of intracellular symbioses is not well understood. To …
Protein kinase a dependent phosphorylation of apical membrane antigen 1 plays an important role in erythrocyte invasion by the malaria parasite
Apicomplexan parasites are obligate intracellular parasites that infect a variety of hosts,
causing significant diseases in livestock and humans. The invasive forms of the parasites …
causing significant diseases in livestock and humans. The invasive forms of the parasites …
Functional analysis of the leading malaria vaccine candidate AMA-1 reveals an essential role for the cytoplasmic domain in the invasion process
A key process in the lifecycle of the malaria parasite Plasmodium falciparum is the fast
invasion of human erythrocytes. Entry into the host cell requires the apical membrane …
invasion of human erythrocytes. Entry into the host cell requires the apical membrane …