Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …

Cancer immunotherapy based on immune-checkpoint inhibition or adoptive cell therapy has
revolutionized cancer care. Nevertheless, a large proportion of patients do not benefit from …

T cells play a critical role in cancer control, but a range of potent immunosuppressive
mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their …

Metastasis has intrigued researchers for more than 100 years. Despite the development of
technologies and therapeutic strategies, metastasis is still the major cause of cancer-related …

Within tumors, some areas are less oxygenated than others. Since their home ground is
under chronic hypoxia, tumor cells adapt to this condition by activating aerobic glycolysis; …

Gap junctions comprise arrays of intercellular channels formed by connexin proteins and
provide for the direct communication between adjacent cells. This type of intercellular …

Approximately 75% of patients with late-stage breast cancer will develop bone metastasis.
This condition is currently considered incurable and patients' life expectancy is limited to 2–3 …

Bone is one of the most common sites of tumor metastases. During the last step of bone
metastasis, cancer cells colonize and disrupt the bone matrix, which is maintained mainly by …

Bone is an active organ that continuously undergoes an orchestrated process of remodeling
throughout life. Bone tissue is uniquely capable of adapting to loading, hormonal, and other …

Purpose: We previously showed that elevated frequencies of peripheral blood CD3+ CD4+
CD127− GARP− CD38+ CD39+ T cells were associated with checkpoint immunotherapy …