Oncogenic mutations in KRAS drive common metabolic programmes that facilitate tumour
survival, growth and immune evasion in colorectal carcinoma, non-small-cell lung cancer …

Cancer is a disease caused by the accumulation of genetic and epigenetic changes in two
types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research …

Pancreatic cancer is the fourth leading cause of cancer-related death among men and
women in the United States. A major challenge in treatment remains patients' advanced …

Follicular thyroid carcinoma (FTC) and benign follicular adenoma (FA) are indistinguishable
by preoperative diagnosis due to their similar histological features. Here we report the first …

Intermediary metabolism generates substrates for chromatin modification, enabling the
potential coupling of metabolic and epigenetic states. Here we identify a network linking …

Peutz–Jeghers syndrome (PJS, MIM175200) is an autosomal dominant condition defined by
the development of characteristic polyps throughout the gastrointestinal tract and …

Pancreatic cancer remains a major unsolved health problem, with conventional cancer
treatments having little impact on disease course. Almost all patients who have pancreatic …

Background & Aims: The Peutz–Jeghers syndrome (PJS) is an autosomal dominant
polyposis disorder with increased risk of multiple cancers, but literature estimates of risk …

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the
United States with a median survival of< 6 mo and a dismal 5-yr survival rate of 3%–5%. The …

Pancreatic cancer, although infrequent, has an exceptionally high mortality rate, making it
one of the four or five most common causes of cancer mortality in developed countries. The …