New information regarding neuronal circuits that control food intake and their hormonal
regulation has extended our understanding of energy homeostasis, the process whereby …

Serotonin has been implicated in the control of satiety for almost four decades. Historically,
the insight that the appetite suppressant effect of fenfluramine is linked to serotonin has …

Background: Obesity and depression co-occur in a significant proportion of the population.
Mechanisms linking the two disorders include the immune and the endocrine system …

Obesity may be a low-grade systemic inflammatory disease. Overweight and obese children
and adults have elevated serum levels of C-reactive protein, interleukin-6, tumor necrosis …

Aggressive behavior in male and female mice occurs in conflicts with intruding rivals, most
often for the purpose of suppressing the reproductive success of the opponent. The …

The adipose-derived hormone leptin is well known for its function in the control of energy
homeostasis. Recent studies suggest a novel role for this adipokine in the regulation of …

The serotonin molecule has some remarkable properties. It is synthesized by two different
genes at two different sites, and, surprisingly, plays antagonistic functions on bone mass …

The identification of leptin as the product of the obesity (ob) gene has been followed by
extensive research identifying a wide spectrum of physiological effects elicited by this …

While many questions remain unanswered, it is now well documented that, contrary to
earlier views, insulin is an important neuromodulator, contributing to neurobiological …

In the past 100 y, there has been a dramatic increase in the number and proportion of
people living into old age in Western countries. The proportion of the population that is …