Computational tools for aptamer identification and optimization

D Sun, M Sun, J Zhang, X Lin, Y Zhang, F Lin… - TrAC Trends in …, 2022 - Elsevier
Aptamers are single-stranded DNA or RNA oligonucleotides that can selectively bind to a
specific target. They are generally obtained by SELEX, but the procedure is challenging and …

Computational frontiers in aptamer-based nanomedicine for precision therapeutics: a comprehensive review

S Kumar, A Mohan, NR Sharma, A Kumar… - ACS …, 2024 - ACS Publications
In the rapidly evolving landscape of nanomedicine, aptamers have emerged as powerful
molecular tools, demonstrating immense potential in targeted therapeutics, diagnostics, and …

Selecting antibacterial aptamers against the BamA protein in Pseudomonas aeruginosa by incorporating genetic algorithm to optimise computational screening …

R Selvam, IHY Lim, JC Lewis, CH Lim, MKK Yap… - Scientific Reports, 2023 - nature.com
Antibiotic resistance is one of the biggest threats to global health resulting in an increasing
number of people suffering from severe illnesses or dying due to infections that were once …

A review: Construction of aptamer screening methods based on improving the screening rate of key steps

X Wei, P Ma, KI Mahmood, Y Zhang, Z Wang - Talanta, 2023 - Elsevier
Aptamers, as recognition molecules, play an important role in the field of detection and
control. Screening is the key procedure to obtain aptamers. Improving the aptamer …

Machine learning directed aptamer search from conserved primary sequences and secondary structures

J Perez Tobia, PJJ Huang, Y Ding… - ACS Synthetic …, 2023 - ACS Publications
Computer-aided prediction of aptamer sequences has been focused on primary sequence
alignment and motif comparison. We observed that many aptamers have a conserved …

Recent Advances in Aptamer-Based Biosensors for Bacterial Detection

V Léguillier, B Heddi, J Vidic - Biosensors, 2024 - mdpi.com
The rapid and sensitive detection of pathogenic bacteria is becoming increasingly important
for the timely prevention of contamination and the treatment of infections. Biosensors based …

High-throughput and computational techniques for aptamer design

RK Kar - Expert Opinion on Drug Discovery, 2024 - Taylor & Francis
Introduction Aptamers refer to short ssDNA/RNA sequences that target small molecules,
proteins, or cells. Aptamers have significantly advanced diagnostic applications, including …

Nucleic acid-responsive smart systems for controlled cargo delivery

A Hasanzadeh, A Ebadati, S Saeedi, B Kamali… - Biotechnology …, 2024 - Elsevier
Stimulus-responsive delivery systems allow controlled, highly regulated, and efficient
delivery of various cargos while minimizing side effects. Owing to the unique properties of …

Diversifying design of nucleic acid aptamers using unsupervised machine learning

S Moussa, M Kilgour, C Jans… - The Journal of …, 2022 - ACS Publications
Inverse design of short single-stranded RNA and DNA sequences (aptamers) is the task of
finding sequences that satisfy a set of desired criteria. Relevant criteria may be, for example …

AptaDB: a comprehensive database integrating aptamer–target interactions

L Chen, Z Yu, Z Wu, M Zhou, Y Wang, X Yu, W Li, G Liu… - RNA, 2024 - rnajournal.cshlp.org
Aptamers have emerged as research hotspots of the next generation due to excellent
performance benefits and application potentials in pharmacology, medicine, and analytical …