Innate immune dysfunction and neuroinflammation in autism spectrum disorder (ASD)
HK Hughes, RJ Moreno, P Ashwood - Brain, behavior, and immunity, 2023 - Elsevier
Autism spectrum disorder (ASD) is a highly heterogeneous neurodevelopmental disorder
characterized by communication and social behavior deficits. The presence of restricted and …
characterized by communication and social behavior deficits. The presence of restricted and …
Immune influencers in action: metabolites and enzymes of the tryptophan-kynurenine metabolic pathway
M Tanaka, F Tóth, H Polyák, Á Szabó, Y Mándi… - Biomedicines, 2021 - mdpi.com
The tryptophan (TRP)-kynurenine (KYN) metabolic pathway is a main player of TRP
metabolism through which more than 95% of TRP is catabolized. The pathway is activated …
metabolism through which more than 95% of TRP is catabolized. The pathway is activated …
Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications
CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …
Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses
A Modabbernia, E Velthorst, A Reichenberg - Molecular autism, 2017 - Springer
Background According to recent evidence, up to 40–50% of variance in autism spectrum
disorder (ASD) liability might be determined by environmental factors. In the present paper …
disorder (ASD) liability might be determined by environmental factors. In the present paper …
Emerging roles for the gut microbiome in autism spectrum disorder
Autism spectrum disorder (ASD) is a serious neurodevelopmental disorder that affects one
in 45 children in the United States, with a similarly striking prevalence in countries around …
in 45 children in the United States, with a similarly striking prevalence in countries around …
From the genetic architecture to synaptic plasticity in autism spectrum disorder
T Bourgeron - Nature Reviews Neuroscience, 2015 - nature.com
Genetics studies of autism spectrum disorder (ASD) have identified several risk genes that
are key regulators of synaptic plasticity. Indeed, many of the risk genes that have been …
are key regulators of synaptic plasticity. Indeed, many of the risk genes that have been …
The fetal origins of mental illness
BJS Al-Haddad, E Oler, B Armistead… - American journal of …, 2019 - Elsevier
The impact of infections and inflammation during pregnancy on the developing fetal brain
remains incompletely defined, with important clinical and research gaps. Although the …
remains incompletely defined, with important clinical and research gaps. Although the …
Aberrations in peripheral inflammatory cytokine levels in Parkinson disease: a systematic review and meta-analysis
Importance The association of nonmotor features and Parkinson disease (PD) is
increasingly recognized. Evidence suggests that inflammation may play a role in PD …
increasingly recognized. Evidence suggests that inflammation may play a role in PD …
Environmental risk factors and biomarkers for autism spectrum disorder: an umbrella review of the evidence
Background Numerous studies have identified potential risk factors and biomarkers for
autism spectrum disorder. We aimed to study the strength and validity of the suggested …
autism spectrum disorder. We aimed to study the strength and validity of the suggested …
Oxidative stress and immune system dysfunction in autism spectrum disorders
L Pangrazzi, L Balasco, Y Bozzi - International journal of molecular …, 2020 - mdpi.com
Autism Spectrum Disorders (ASDs) represent a group of neurodevelopmental disorders
associated with social and behavioral impairments. Although dysfunctions in several …
associated with social and behavioral impairments. Although dysfunctions in several …