Evolutive emergence and divergence of an Ig regulatory node: An environmental sensor getting cues from the aryl hydrocarbon receptor?
P D'Addabbo, D Frezza, CEW Sulentic - Frontiers in Immunology, 2023 - frontiersin.org
One gene, the immunoglobulin heavy chain (IgH) gene, is responsible for the expression of
all the different antibody isotypes. Transcriptional regulation of the IgH gene is complex and …
all the different antibody isotypes. Transcriptional regulation of the IgH gene is complex and …
Systematic characterization and comparative analysis of the rabbit immunoglobulin repertoire
Rabbits have been used extensively as a model system for the elucidation of the mechanism
of immunoglobulin diversification and for the production of antibodies. We employed Next …
of immunoglobulin diversification and for the production of antibodies. We employed Next …
Trials and tribulations with VH replacement
VH replacement (VHR) is a type of antibody gene rearrangement in which an upstream
heavy chain variable gene segment (VH) invades a pre-existing rearrangement (VDJ). In …
heavy chain variable gene segment (VH) invades a pre-existing rearrangement (VDJ). In …
[HTML][HTML] Parallel antibody germline gene and haplotype analyses support the validity of immunoglobulin germline gene inference and discovery
Abstract Analysis of antibody repertoire development and specific antibody responses
important for eg autoimmune conditions, allergy, and protection against disease is …
important for eg autoimmune conditions, allergy, and protection against disease is …
Diversification of immunoglobulin genes by gene conversion in the domestic chicken (Gallus gallus domesticus)
Sustainable modern poultry production depends on effective protection against infectious
diseases and a diverse range of antibodies is key for an effective immune response. In the …
diseases and a diverse range of antibodies is key for an effective immune response. In the …
[HTML][HTML] Gene conversions are under purifying selection in the carcinoembryonic antigen immunoglobulin gene families of primates
The carcinoembryonic antigen (CEA) family contains a large number of glycoproteins
belonging to the immunoglobulin superfamily. Here, we investigate whether the gene …
belonging to the immunoglobulin superfamily. Here, we investigate whether the gene …
Studying antibody repertoires with next-generation sequencing
WD Lees, AJ Shepherd - … : Volume II: Structure, Function, and Applications, 2017 - Springer
Next-generation sequencing is making it possible to study the antibody repertoire of an
organism in unprecedented detail, and, by so doing, to characterize its behavior in the …
organism in unprecedented detail, and, by so doing, to characterize its behavior in the …
Kinetic models reveal the in vivo mechanisms of mutagenesis in microbes and man
BE Wright, KH Schmidt, MF Minnick - Mutation Research/Reviews in …, 2013 - Elsevier
This review summarizes the evidence indicating that mutagenic mechanisms in vivo are
essentially the same in all living cells. Unique metabolic reactions to a particular …
essentially the same in all living cells. Unique metabolic reactions to a particular …
Immunogenetics in the rabbit.
RG Mage, C Rogel-Gaillard - The genetics and genomics of …, 2021 - cabidigitallibrary.org
This chapter on immunogenetics in the rabbit focused on some genes with genetic and
genomic sequence information including those encoding: soluble circulating …
genomic sequence information including those encoding: soluble circulating …
Characterization of a new V gene replacement in the absence of activation‐induced cytidine deaminase and its contribution to human B‐cell receptor diversity
H Ouled‐Haddou, H Ghamlouch, A Regnier… - …, 2014 - Wiley Online Library
In B cells, B‐cell receptor (BCR) immunoglobulin revision is a common route for modifying
unwanted antibody specificities via a mechanism called VH replacement. This in vivo …
unwanted antibody specificities via a mechanism called VH replacement. This in vivo …