Epistasis occurs when the effect of a mutation depends on its carrier's genetic background.
Despite increasing evidence that epistasis for fitness is common, its role during evolution is …

Many microbial populations rapidly adapt to changing environments with multiple variants
competing for survival. To quantify such complex evolutionary dynamics in vivo, time …

Much of the current theory of adaptation is based on Gillespie's mutational landscape model
(MLM), which assumes that the fitness values of genotypes linked by single mutational steps …

The bistably expressed K‐state of B acillus subtilis is characterized by two distinct features;
transformability and arrested growth when K‐state cells are exposed to fresh medium. The …

The origin and evolution of sex, and the associated role of recombination, present a major
problem in biology. Sex typically involves recombination of closely related DNA or RNA …

Kauffman's NK-model is a paradigmatic example of a class of stochastic models of genotypic
fitness landscapes that aim to capture generic features of epistatic interactions in multilocus …

How does standing genetic variation affect polygenic adaptation in recombining
populations? Despite a large body of work in quantitative genetics, epistatic and weak …

In the stationary phase, Bacillus subtilis differentiates stochastically and transiently into the
state of competence for transformation (K-state). The latter is associated with growth arrest …

Sex is ubiquitous in the natural world, but the nature of its benefits remains controversial.
Previous studies have suggested that a major advantage of sex is its ability to eliminate …

Numerous empirical studies have witnessed an increase in meiotic recombination rate in
response to physiological stress imposed by unfavorable environmental conditions. Thus …