[HTML][HTML] GLP-1 receptor agonists (GLP-1RAs): cardiovascular actions and therapeutic potential
Type 2 diabetes mellitus (T2DM) is closely associated with cardiovascular diseases (CVD),
including atherosclerosis, hypertension and heart failure. Some anti-diabetic medications …
including atherosclerosis, hypertension and heart failure. Some anti-diabetic medications …
Encapsulation of tannins and tannin-rich plant extracts by complex coacervation to improve their physicochemical properties and biological activities: A review
As a major class of dietary polyphenols, tannins are demonstrated to have various health-
promoting properties. Although tannins have been widely utilized in food, pharmaceutical …
promoting properties. Although tannins have been widely utilized in food, pharmaceutical …
Receptor-mediated ER export of lipoproteins controls lipid homeostasis in mice and humans
X Wang, H Wang, B Xu, D Huang, C Nie, L Pu… - Cell Metabolism, 2021 - cell.com
Efficient delivery of specific cargos in vivo poses a major challenge to the secretory pathway,
which shuttles products encoded by∼ 30% of the genome. Newly synthesized protein and …
which shuttles products encoded by∼ 30% of the genome. Newly synthesized protein and …
[HTML][HTML] A gut-derived hormone regulates cholesterol metabolism
X Hu, F Chen, L Jia, A Long, Y Peng, X Li, J Huang… - Cell, 2024 - cell.com
The reciprocal coordination between cholesterol absorption in the intestine and de novo
cholesterol synthesis in the liver is essential for maintaining cholesterol homeostasis, yet the …
cholesterol synthesis in the liver is essential for maintaining cholesterol homeostasis, yet the …
Altered blood gene expression in the obesity-related type 2 diabetes cluster may be causally involved in lipid metabolism: a Mendelian randomisation study
Aims/hypothesis The aim of this study was to identify differentially expressed long non-
coding RNAs (lncRNAs) and mRNAs in whole blood of people with type 2 diabetes across …
coding RNAs (lncRNAs) and mRNAs in whole blood of people with type 2 diabetes across …
Periodontitis exacerbates atherosclerosis through Fusobacterium nucleatum-promoted hepatic glycolysis and lipogenesis
LJ Zhou, WZ Lin, XQ Meng, H Zhu, T Liu… - Cardiovascular …, 2023 - academic.oup.com
Aims Positive associations between periodontitis (PD) and atherosclerosis have been
established, but the causality and mechanisms are not clear. We aimed to explore the …
established, but the causality and mechanisms are not clear. We aimed to explore the …
[HTML][HTML] ERK1/2 inhibition reduces vascular calcification by activating miR-126-3p-DKK1/LRP6 pathway
P Zeng, J Yang, L Liu, X Yang, Z Yao, C Ma, H Zhu… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Vascular microcalcification increases the risk of rupture of vulnerable
atherosclerotic lesions. Inhibition of ERK1/2 reduces atherosclerosis in animal models while …
atherosclerotic lesions. Inhibition of ERK1/2 reduces atherosclerosis in animal models while …
[HTML][HTML] Animal model for tendinopathy
Background Tendinopathy is a common motor system disease that leads to pain and
reduced function. Despite its prevalence, our mechanistic understanding is incomplete …
reduced function. Despite its prevalence, our mechanistic understanding is incomplete …
VLDL Biogenesis and Secretion: it takes a village
W Van Zwol, B Van De Sluis, HN Ginsberg… - Circulation …, 2024 - Am Heart Assoc
The production and secretion of VLDLs (very-low-density lipoproteins) by hepatocytes has a
direct impact on liver fat content, as well as the concentrations of cholesterol and …
direct impact on liver fat content, as well as the concentrations of cholesterol and …
Identifying G protein-coupled receptors involved in adipose tissue function using the innovative RNA-seq database FATTLAS
G protein-coupled receptors (GPCRs) modulate the function of adipose tissue (AT) in
general and of adipocytes, specifically. Although it is well-established that GPCRs are …
general and of adipocytes, specifically. Although it is well-established that GPCRs are …