Next-generation DNA sequencing technology has dramatically advanced clinical oncology
through the identification of therapeutic targets and molecular biomarkers, leading to the …

Cell-free DNA molecules are released into the plasma via apoptotic or necrotic events and
active release mechanisms, which carry the genetic and epigenetic information of its origin …

Land-use and land-cover (LULC) changes have become a crucial issue that urgently needs
to be addressed due to global environmental change. Many studies have employed remote …

Cell-free DNA (cfDNA) in urine is a promising analyte for noninvasive diagnostics. However,
urine cfDNA is highly fragmented. Whether characteristics of these fragments reflect …

Deeper and broader sequencing of circulating tumor DNA (ctDNA) has identified a wealth of
cancer markers in the circulation, resulting in a paradigm shift towards data science-driven …

Circulating cell-free DNA (cfDNA) is a promising biomarker for the diagnosis and prognosis
of many diseases, including cancer. The genome-wide non-random fragmentation patterns …

Advances in sequencing technologies facilitate personalized disease-risk profiling and
clinical diagnosis. In recent years, some great progress has been made in noninvasive …

Colorectal cancer (CRC) is among the most common cancers globally and a major cause of
cancer-related deaths. The American Cancer Society estimates that CRC will kill 1 in 60 …

Abstract Background and Purpose Current radiotherapy guidelines rely heavily on imaging-
based monitoring. Liquid biopsy monitoring promises to complement imaging by providing …

Early cancer detection and localization using cell-free DNA (cfDNA) faces multiple
challenges, including the low fraction of tumor DNA in cfDNA and the molecular …