Defining the risk of SARS-CoV-2 variants on immune protection
The global emergence of many severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) variants jeopardizes the protective antiviral immunity induced after infection or …
CoV-2) variants jeopardizes the protective antiviral immunity induced after infection or …
Synthetic biology-inspired cell engineering in diagnosis, treatment, and drug development
N Zhao, Y Song, X Xie, Z Zhu, C Duan… - … and Targeted Therapy, 2023 - nature.com
The fast-developing synthetic biology (SB) has provided many genetic tools to reprogram
and engineer cells for improved performance, novel functions, and diverse applications …
and engineer cells for improved performance, novel functions, and diverse applications …
A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2
The ideal vaccine against viruses such as influenza and SARS-CoV-2 must provide a
robust, durable and broad immune protection against multiple viral variants. However …
robust, durable and broad immune protection against multiple viral variants. However …
Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques
Type I interferons (IFN-I) are critical mediators of innate control of viral infections but also
drive the recruitment of inflammatory cells to sites of infection, a key feature of severe …
drive the recruitment of inflammatory cells to sites of infection, a key feature of severe …
Immunostimulatory polymers as adjuvants, immunotherapies, and delivery systems
Activating innate immunity in a controlled manner is necessary for the development of next-
generation therapeutics. Adjuvants, or molecules that modulate the immune response, are …
generation therapeutics. Adjuvants, or molecules that modulate the immune response, are …
Advances in SARS-CoV-2 receptor-binding domain-based COVID-19 vaccines
ABSTRACT Introduction The Coronavirus Disease 2019 (COVID-19) pandemic has caused
devastating human and economic costs. Vaccination is an important step in controlling the …
devastating human and economic costs. Vaccination is an important step in controlling the …
A novel RBD-protein/peptide vaccine elicits broadly neutralizing antibodies and protects mice and macaques against SARS-CoV-2
S Wang, CY Wang, HK Kuo, WJ Peng… - Emerging Microbes & …, 2022 - Taylor & Francis
The development of safe and effective vaccines to respond to COVID-19 pandemic/endemic
remains a priority. We developed a novel subunit protein-peptide COVID-19 vaccine …
remains a priority. We developed a novel subunit protein-peptide COVID-19 vaccine …
[HTML][HTML] NLRP3 inflammasome activation and SARS-CoV-2-mediated hyperinflammation, cytokine storm and neurological syndromes
Despite the introduction of vaccines and drugs for SARS-CoV-2, the COVID-19 pandemic
continues to spread throughout the world. In severe COVID-19 patients, elevated levels of …
continues to spread throughout the world. In severe COVID-19 patients, elevated levels of …
Developing a multiepitope vaccine for the prevention of SARS-CoV-2 and monkeypox virus co-infection: a reverse vaccinology analysis
F Jiang, Y Liu, Y Xue, P Cheng, J Wang, J Lian… - International …, 2023 - Elsevier
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and
monkeypox virus (MPXV) severely threaten human health; however, currently, no vaccine …
monkeypox virus (MPXV) severely threaten human health; however, currently, no vaccine …
Recombinant vaccines in 2022: a perspective from the cell factory
MT de Pinho Favaro, J Atienza-Garriga… - Microbial cell …, 2022 - Springer
The last big outbreaks of Ebola fever in Africa, the thousands of avian influenza outbreaks
across Europe, Asia, North America and Africa, the emergence of monkeypox virus in …
across Europe, Asia, North America and Africa, the emergence of monkeypox virus in …