Noise-induced hearing loss (NIHL) can lead to secondary changes that induce neural
plasticity in the central auditory pathway. These changes include decreases in the number of …

Genetic hearing loss is a common health problem with no effective therapy currently
available. DFNA15, caused by mutations of the transcription factor POU4F3, is one of the …

The organ of Corti is an auditory organ located in the cochlea, comprising hair cells (HCs)
and other supporting cells. Cellular shape changes of HCs are important for the …

Objective: This study aimed to test the hearing function and to investigate the effect of
estrogen on prestin and MYO7A expression in hair cells of the cochlea in ovariectomized …

In the receptor organs of the inner ear and lateral line, sensory hair cells detect mechanical
stimuli such as sounds, accelerations, and water movements. In each instance a stimulus …

Myosin light chain kinase (MLCK) phosphorylates myosin regulatory light chains to facilitate
its interaction with actin filaments and produce contractile activity. The outer hair cells …

An eight‑base pair (bp) deletion in the Pou4f3 gene in hair cells is associated with DFNA15,
a hereditary form of hearing loss. To explore the pathological mechanisms underlying the …

Noise-induced hearing loss (NIHL) is one of the most common auditory disorders and a
major socioeconomic problem. NIHL can lead to secondary changes that induce neural …

In the process of generating antibodies against cell surface antigens on human embryonic
stem cells (hESCs) by immunization with live hESCs, several cytotoxic monoclonal …