Introduction Interindividual differences in drug response are a frequent clinical challenge
partly due to variation in pharmacokinetics. ATP-binding cassette (ABC) transporters are …

Pharmacogenetic research has the potential to explain the variation in treatment efficacy
within patient populations. Understanding the interaction between genetic variation and …

Opioid-related respiratory depression (RD) is a serious clinical problem as it causes multiple
deaths and anoxic brain injuries. Morphine is subject to efflux via P-glycoprotein transporter …

Background Genetic variability may influence methadone metabolism, dose requirements,
and risk of relapse. Objectives To determine whether the CYP2B6* 6 or ABCB1 (rs1045642) …

Background Adequate opioid prescribing is critical for therapeutic success of pain
management. Despite the widespread use of opioids, optimized opioid therapy remains …

Methadone is utilized for the treatment of individuals with opiate dependence. Methadone
undergoes N-demethylation by multiple cytochrome P450 (CYP) enzymes including …

This paper is the thirty-sixth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2013 …

Methods We conducted 2 phase 1, double-blind, randomized, placebo-controlled, single-
and multiple-ascending-dose studies to investigate the safety and tolerability of oral d …

Opioid use disorder (OUD) is a significant health problem in the United States and many
other countries. A combination of issues, most notably increased prescription of opioid …

Objective Anaesthesiology guidelines suggest that opioids worsen obstructive sleep apnoea
(OSA) despite no randomised controlled trial evidence. We therefore conducted a …