Cancer is a multistep disease driven by the activation of specific oncogenic pathways
concomitantly with the loss of function of tumor suppressor genes that act as sentinels to …

After years of extensive scientific discovery much has been learned about the networks that
regulate epithelial homeostasis. Loss of expression or functional activity of cell adhesion …

Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in∼
30% of patients with breast cancer. However, many patients have residual cancer after …

The highly conserved c-Jun N-terminal Kinase (JNK) signalling pathway has many
functions, regulating a diversity of processes: from cell movement during embryogenesis to …

The study of Drosophila imaginal discs has contributed to a number of discoveries in
developmental and cellular biology. In addition to the elucidation of the role of tissue …

The Scribble cell polarity module, comprising Scribbled (Scrib), Discs-large (Dlg) and Lethal-
2-giant larvae (Lgl), has a tumor suppressive role in mammalian epithelial cancers. The …

Epithelia form intelligent, dynamic barriers between the external environment and an
organism's interior. Intercellular cadherin-based adhesions adapt and respond to …

Cancer is driven by complex genetic and cellular mechanisms. Recently, the Drosophila
community has become increasingly interested in exploring cancer issues. The Drosophila …

Conservation of major signaling pathways between humans and flies has made Drosophila
a useful model organism for cancer research. Our understanding of the mechanisms …

Rho GTPases are critical signal transducers of multiple pathways. They have been
proposed to be useful anti-neoplastic targets for over two decades, especially in Ras-driven …