Ghrelin, a peptide hormone predominantly produced by the stomach, was isolated as the
endogenous ligand for the growth hormone secretagogue receptor. Ghrelin is a potent …

The past couple of years have seen several novel X-ray structures of 7 transmembrane
(7TM) receptors in complex with antagonists and even with a peptide fragment of a G …

Opioids represent widely prescribed and abused medications, although their signal
transduction mechanisms are not well understood. Here we present the 1.8 Å high …

We identified subsets of neurons in the brain that coexpress the dopamine receptor subtype-
2 (DRD2) and the ghrelin receptor (GHSR1a). Combination of FRET confocal microscopy …

Ghrelin, also called “the hunger hormone”, is a gastric peptide hormone that regulates food
intake, body weight, as well as taste sensation, reward, cognition, learning and memory …

Anorexia nervosa (AN) is classically defined as a condition in which an abnormally low body
weight is associated with an intense fear of gaining weight and distorted cognitions …

Despite its central role in signaling and the potential therapeutic applications of inverse
agonists, the molecular mechanisms underlying G protein-coupled receptor (GPCR) …

Ghrelin is an orexigenic peptide predominantly secreted from the stomach and stimulates
appetite and growth hormone (GH) release. Studies have provided evidence that ghrelin …

Specifically addressing cell surface molecules on cancer cells facilitates targeted cancer
therapies that offer the potential to selectively destroy malignant cells, while sparing healthy …

The G protein-coupled receptor GHS-R1a mediates ghrelin-induced growth hormone
secretion, food intake, and reward-seeking behaviors. GHS-R1a signals through G q, G i/o …