In contrast to solid cancers, which often require genetic modifications and complex cellular
reprogramming for effective metastatic dissemination, leukaemic cells uniquely possess the …

Decades of research have established atherosclerosis as an inflammatory disease. Only
recently though, clinical trials provided proof-of-concept evidence for the efficacy of anti …

Autologous hematopoietic stem cell transplantation (ASCT) improves survival in multiple
myeloma (MM). However, many individuals are unable to collect optimal CD34+ …

Purpose To update the 2006 American Society of Clinical Oncology guideline on the use of
hematopoietic colony-stimulating factors (CSFs). Methods The American Society of Clinical …

This is the sixth special report that the European Society for Blood and Marrow
Transplantation regularly publishes on the current practice and indications for …

Chemokines, small proinflammatory chemoattractant cytokines that bind to specific G-protein-
coupled seven-span transmembrane receptors, are major regulators of cell trafficking and …

Activation of the chemokine receptor CXCR4 by its chemokine ligand CXCL12 regulates
diverse cellular processes. Previously reported crystal structures of CXCR4 revealed the …

Classical chemotherapeutic anti-cancer treatments induce cell death through DNA damage
by taking advantage of the proliferative behaviour of cancer cells. The more recent approach …

Autologous hematopoietic stem cell transplantation (aHSCT) is a well-established treatment
for malignancies such as multiple myeloma (MM) and lymphomas. Various changes in the …

In most countries, healthcare service budgets are not likely to support the current explosion
in the cost of new oncology drugs. Repurposing the large arsenal of approved, non …