Colorectal cancer (CRC) is one of the most prevalent cancers affecting humans, with a
complex genetic and environmental aetiology. Unlike cancers with known environmental …

Developmental biology has long benefited from studies of classic model organisms.
Recently, human pluripotent stem cells (hPSCs), including human embryonic stem cells and …

A complex interplay of environmental factors impacts the metabolism of human cells, but
neither traditional culture media nor mouse plasma mimic the metabolite composition of …

The use of mice as model organisms to study human biology is predicated on the genetic
and physiological similarities between the species. Nonetheless, mice and humans have …

Animal models play a central role in all areas of biomedical research. The process of animal
model building, development and evaluation has rarely been addressed systematically …

De novo mutations are known to play a prominent role in sporadic disorders with reduced
fitness. We hypothesize that de novo mutations play an important role in severe male …

Developed decades ago, traditional culture media were not intended to resemble the
metabolic composition of human blood, and indeed poorly do so. Yet, despite what is now a …

In behavioral neurosciences, such as neurobiology and biopsychology, animal models
make it possible to investigate brain–behavior relations, with the aim of gaining insight into …

Human development and disease are challenging to study because of lack of experimental
accessibility to in vivo systems and the complex nature of biological processes. For these …

Cardiotoxicity, also referred to as drug-induced cardiac injury, is an issue associated with
the use of some small-molecule kinase inhibitors and antibody-based therapies targeting …