The pathologic paradigm for renal progression is advancing tubulointerstitial fibrosis.
Whereas mechanisms underlying fibrogenesis have grown in scope and understanding in …

Highlights•More than 60 zebrafish chemical screens have been reported since 2000.•We
summarize the current practices in design of high-throughput zebrafish screens.•We …

Acute kidney injury (AKI) is considered largely reversible based on the capacity of surviving
tubular cells to dedifferentiate and replace lost cells via cell division. Here we show by …

Studies have highlighted the importance of histone deacetylase (HDAC)-mediated
epigenetic processes in the development of diabetic complications. Inhibitors of HDAC are a …

The zebrafish is a powerful toxicity model; biochemical assays can be combined with
observations at a structural and functional level within one individual. This mini review …

At present, there are no effective therapies to ameliorate injury, accelerate recovery, or
prevent postinjury fibrosis after AKI. Here, we sought to identify candidate compounds that …

The vitamin A (retinol) metabolite, all-trans retinoic acid (RA), is a signaling molecule that
plays key roles in the development of the body plan and induces the differentiation of many …

Human disease and biological practices are modelled in zebrafish (Danio rerio) at various
phases of drug development as well as toxicity evaluation. The zebrafish is ideal for in vivo …

Acute kidney injury (AKI) is defined by a rapid decline in renal function. Regardless of the
initial cause of injury, the influx of immune cells is a common theme during AKI. While an …

Vertebrates form a progressive series of up to three kidney organs during development—the
pronephros, mesonephros, and metanephros. Each kidney derives from the intermediate …