Peptide hormone regulation of angiogenesis
It is now apparent that regulation of blood vessel growth contributes to the classical actions
of hormones on development, growth, and reproduction. Endothelial cells are ideally …
of hormones on development, growth, and reproduction. Endothelial cells are ideally …
[HTML][HTML] Prolactin and the skin: a dermatological perspective on an ancient pleiotropic peptide hormone
K Foitzik, EA Langan, R Paus - Journal of Investigative Dermatology, 2009 - Elsevier
The polypeptide hormone prolactin (PRL) is best known as the pituitary modulator of
lactation and reproduction. However, based on the almost ubiquitous distribution of PRL …
lactation and reproduction. However, based on the almost ubiquitous distribution of PRL …
[HTML][HTML] Transcriptomic analysis across nasal, temporal, and macular regions of human neural retina and RPE/choroid by RNA-Seq
Proper spatial differentiation of retinal cell types is necessary for normal human vision. Many
retinal diseases, such as Best disease and male germ cell associated kinase (MAK) …
retinal diseases, such as Best disease and male germ cell associated kinase (MAK) …
Regulation of blood vessels by prolactin and vasoinhibins
Prolactin (PRL) stimulates the growth of new blood vessels (angiogenesis) either directly
through actions on endothelial cells or indirectly by upregulating proangiogenic factors like …
through actions on endothelial cells or indirectly by upregulating proangiogenic factors like …
Matrix metalloproteases from chondrocytes generate an antiangiogenic 16 kDa prolactin
Y Macotela, MB Aguilar… - Journal of cell …, 2006 - journals.biologists.com
The 16 kDa N-terminal fragment of prolactin (16K-prolactin) is a potent antiangiogenic factor.
Here, we demonstrate that matrix metalloproteases (MMPs) produced and secreted by …
Here, we demonstrate that matrix metalloproteases (MMPs) produced and secreted by …
Recent advances in ocular drug delivery systems and targeting VEGF receptors for management of ocular angiogenesis: A comprehensive review
Background Angiogenic ocular diseases address the main source of vision impairment or
irreversible vision loss. The angiogenesis process depends on the balance between the pro …
irreversible vision loss. The angiogenesis process depends on the balance between the pro …
Autocrine/paracrine roles of extrapituitary growth hormone and prolactin in health and disease: An overview
S Harvey, CG Martínez-Moreno, M Luna… - General and …, 2015 - Elsevier
Growth hormone (GH) and prolactin (PRL) are both endocrines that are synthesized and
released from the pituitary gland into systemic circulation. Both are therefore hormones and …
released from the pituitary gland into systemic circulation. Both are therefore hormones and …
Ocular angiogenesis: mechanisms and recent advances in therapy
M Rajappa, P Saxena, J Kaur - Advances in clinical chemistry, 2010 - Elsevier
Ocular angiogenesis, the formation of new blood vessels from the existing vascular tree, is
an important cause for severe loss of vision. It can occur in a spectrum of ocular disorders …
an important cause for severe loss of vision. It can occur in a spectrum of ocular disorders …
High levels of serum prolactin protect against diabetic retinopathy by increasing ocular vasoinhibins
E Arnold, JC Rivera, S Thebault, D Moreno-Páramo… - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE Increased retinal vasopermeability (RVP) occurs early in diabetes and is crucial
for the development of sight-threatening proliferative diabetic retinopathy (DR). The …
for the development of sight-threatening proliferative diabetic retinopathy (DR). The …
Vasoinhibins: endogenous regulators of angiogenesis and vascular function
Vasoinhibins are a family of peptides derived from prolactin, growth hormone and placental
lactogen that act on endothelial cells to suppress vasodilation and angiogenesis and to …
lactogen that act on endothelial cells to suppress vasodilation and angiogenesis and to …