For over 60 years, the synthetic production of new DNA sequences has helped researchers
understand and engineer biology. Here we summarize methods and caveats for the de novo …

Protein–protein interactions (PPIs) have emerged as important and challenging targets in
chemical biology and medicinal chemistry. The main difficulty encountered in the discovery …

Abstract The Eukaryotic Linear Motif (ELM) resource (http://elm. eu. org) is a manually
curated database of short linear motifs (SLiMs). In this update, we present the latest …

Specific protein–protein interactions are central to all processes that underlie cell
physiology. Numerous studies have together identified hundreds of thousands of human …

Accumulation of α-synuclein into toxic oligomers or fibrils is implicated in dopaminergic
neurodegeneration in Parkinson's disease. Here we performed a high-throughput, proteome …

Short sequence motifs are ubiquitous across the three major types of biomolecules:
hundreds of classes and thousands of instances of DNA regulatory elements, RNA motifs …

Short linear motifs (SLiMs) are a unique and ubiquitous class of protein interaction modules
that perform key regulatory functions and drive dynamic complex formation. For decades …

Viral proteins make extensive use of short peptide interaction motifs to hijack cellular host
factors. However, most current large-scale methods do not identify this important class of …

Key events ranging from cell polarity to proliferation regulation to neuronal signaling rely on
the assembly of multiprotein adhesion or signaling complexes at particular subcellular sites …

Intrinsically disordered proteins (IDPs) constitute a broad set of proteins with few uniting and
many diverging properties. IDPs—and intrinsically disordered regions (IDRs) interspersed …