[HTML][HTML] Assembly of the Escherichia coli NADH: ubiquinone oxidoreductase (respiratory complex I)

T Friedrich, DK Dekovic, S Burschel - Biochimica Et Biophysica Acta (BBA) …, 2016 - Elsevier
Energy-converting NADH: ubiquinone oxidoreductase, respiratory complex I, couples the
electron transfer from NADH to ubiquinone with the translocation of four protons across the …

The 'liaisons dangereuses' between iron and antibiotics

B Ezraty, F Barras - FEMS microbiology reviews, 2016 - academic.oup.com
The decline in the rate of new antibiotic discovery is of growing concern, and new
antibacterial strategies must now be explored. This review brings together research in two …

Mutations in respiratory complex I promote antibiotic persistence through alterations in intracellular acidity and protein synthesis

B Van den Bergh, H Schramke, JE Michiels… - Nature …, 2022 - nature.com
Antibiotic persistence describes the presence of phenotypic variants within an isogenic
bacterial population that are transiently tolerant to antibiotic treatment. Perturbations of …

Adaptive laboratory evolution of antibiotic resistance using different selection regimes lead to similar phenotypes and genotypes

LJ Jahn, C Munck, MMH Ellabaan… - Frontiers in …, 2017 - frontiersin.org
Antibiotic resistance is a global threat to human health, wherefore it is crucial to study the
mechanisms of antibiotic resistance as well as its emergence and dissemination. One way to …

Structure of the peripheral arm of a minimalistic respiratory complex I

J Schimpf, S Oppermann, T Gerasimova, AFS Seica… - Structure, 2022 - cell.com
Respiratory complex I drives proton translocation across energy-transducing membranes by
NADH oxidation coupled with (ubi) quinone reduction. In humans, its dysfunction is …

Lipopolysaccharide -mediated resistance to host antimicrobial peptides and hemocyte-derived reactive-oxygen species are the major Providencia alcalifaciens virulence factors …

M Shaka, A Arias-Rojas, A Hrdina, D Frahm… - PLoS …, 2022 - journals.plos.org
Bacteria from the genus Providencia are ubiquitous Gram-negative opportunistic pathogens,
causing “travelers' diarrhea”, urinary tract, and other nosocomial infections in humans. Some …

Mycobacterium tuberculosis protein MoxR1 enhances virulence by inhibiting host cell death pathways and disrupting cellular bioenergetics

N Quadir, M Shariq, JA Sheikh, J Singh, N Sharma… - Virulence, 2023 - Taylor & Francis
Mycobacterium tuberculosis (M. tb) utilizes the multifunctionality of its protein factors to
deceive the host. The unabated global incidence and prevalence of tuberculosis (TB) and …

Translation fidelity and respiration deficits in CLPP-deficient tissues: mechanistic insights from mitochondrial complexome profiling

J Key, S Gispert, G Koepf, J Steinhoff-Wagner… - International journal of …, 2023 - mdpi.com
The mitochondrial matrix peptidase CLPP is crucial during cell stress. Its loss causes
Perrault syndrome type 3 (PRLTS3) with infertility, neurodegeneration, and a growth deficit …

Structural characterization of a newly identified component of α-carboxysomes: the AAA+ domain protein CsoCbbQ

M Sutter, EW Roberts, RC Gonzalez, C Bates… - Scientific reports, 2015 - nature.com
Carboxysomes are bacterial microcompartments that enhance carbon fixation by
concentrating ribulose-1, 5-bisphosphate carboxylase/oxygenase (RuBisCO) and its …

Structural insights into ATP hydrolysis by the MoxR ATPase RavA and the LdcI-RavA cage-like complex

M Jessop, B Arragain, R Miras, A Fraudeau… - Communications …, 2020 - nature.com
Abstract The hexameric MoxR AAA+ ATPase RavA and the decameric lysine decarboxylase
LdcI form a 3.3 MDa cage, proposed to assist assembly of specific respiratory complexes in …