All cells possess an internal stress response to cope with environmental and
pathophysiological challenges. Upon stress, cells reprogram their molecular functions to …

The heat-shock response, one of the main pro-survival mechanisms of a living organism,
has evolved as the biochemical response of cells to cope with heat stress. The most well …

HSPA8/HSC70 is a molecular chaperone involved in a wide variety of cellular processes. It
plays a crucial role in protein quality control, ensuring the correct folding and re-folding of …

Alzheimer disease (AD) is a progressive neurodegenerative disorder associated with aging
and characterized pathologically by the presence of senile plaques, neurofibrillary tangles …

Beyond guarding the cellular proteome the major stress inducible heat shock protein Hsp70
has been shown to interact with lipids. Non-cytosolic Hsp70 stabilizes membranes during …

Alzheimer's disease (AD) is an incurable, progressive neurodegenerative disorder. AD is a
complex and multifactorial disease that is responsible for 60–80% of dementia cases. Aging …

The skeletal muscle (SkM) is the largest organ, which plays a vital role in controlling
musculature, locomotion, body heat regulation, physical strength, and metabolism of the …

Neurodegenerative diseases are characterised by the irreversible degeneration of neurons
in the central or peripheral nervous systems. These include amyotrophic lateral sclerosis …

Alzheimer's disease (AD) represents the most common form of dementia, characterized by
amyloid β (Aβ) plaques and neurofibrillary tangles (NFTs). It is characterized by …

The study of Alzheimer's disease (AD) has led to an increased understanding of the multiple
pathologies and pathways of the disease. As such, it has been proposed that AD and its …