Beside digesting nutrients and absorbing solutes and electrolytes, the intestinal epithelium
with its barrier function is in charge of a tightly controlled antigen trafficking from the …

The nature of depression has recently been reconceptualized, being conceived as the
clinical expression of activated immune-inflammatory, oxidative, and nitrosative stress …

Haptoglobin is an acute phase protein that scavenges haemoglobin in the event of
intravascular or extravascular haemolysis. The protein exists in humans as three main …

Abstract Significance: Haptoglobin (Hp) is an abundant human plasma protein that tightly
captures hemoglobin (Hb) during hemolysis. The Hb-Hp complex formation reduces the …

Crohn's disease (CD) and ulcerative colitis (UC), collectively called inflammatory bowel
disease (IBD), are immune-mediated conditions characterized by a chronic inflammation of …

Increased small intestinal permeability (IP) has been proposed to be an integral element,
along with genetic makeup and environmental triggers, in the pathogenies of chronic …

Haptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind
free hemoglobin (Hb) and prevent the loss of iron and subsequent kidney damage following …

Non-allelic homologous recombination (NAHR) is a common mechanism for generating
genome rearrangements and is implicated in numerous genetic disorders, but its detection …

Background Genome-wide association studies have identified nearly 20 susceptibility loci
for IgA nephropathy. However, most nonsynonymous coding variants, particularly those …

Background Haptoglobin (Hp) is a haemoglobin-binding protein with immunomodulatory
properties. Its gene (16q22) harbours a common polymorphism with two different alleles …