Genetic and covalent protein modification strategies to facilitate intracellular delivery

JM Horn, AC Obermeyer - Biomacromolecules, 2021 - ACS Publications
Protein-based therapeutics represent a rapidly growing segment of approved disease
treatments. Successful intracellular delivery of proteins is an important precondition for …

Trapped! A critical evaluation of methods for measuring total cellular uptake versus cytosolic localization

K Deprey, L Becker, J Kritzer… - Bioconjugate …, 2019 - ACS Publications
Biomolecules have many properties that make them promising for intracellular therapeutic
applications, but delivery remains a key challenge because large biomolecules cannot …

A safe and potentiated multi-type HPV L2-E7 nanoparticle vaccine with combined prophylactic and therapeutic activity

X Zhao, Y Zhang, O Trejo-Cerro, E Kaplan, Z Li… - npj Vaccines, 2024 - nature.com
Persistent infection with high-risk human papillomavirus (HPV) is widely recognized as the
primary cause of cervical and other malignant cancers. There are six licensed prophylactic …

Improved transfer efficiency of supercharged 36+ GFP protein mediate nucleic acid delivery

L Wang, J Geng, L Chen, X Guo, T Wang, Y Fang… - Drug Delivery, 2022 - Taylor & Francis
The potential of nucleic acid therapeutics to treat diseases by targeting specific cells has
resulted in its increasing number of uses in clinical settings. However, the major challenge is …

Comparison of six cell penetrating peptides with different properties for in vitro and in vivo delivery of HPV16 E7 antigen in therapeutic vaccines

S Shahbazi, A Bolhassani - International Immunopharmacology, 2018 - Elsevier
The high risk human papillomavirus (HPV) types 16 and 18 are globally linked to> 50% and
20% of all cervical cancers, respectively. The HPV E7 oncoprotein was determined as a …

Improvements in chemical carriers of proteins and peptides

A Bolhassani - Cell Biology International, 2019 - Wiley Online Library
The successful intracellular delivery of biologically active proteins and peptides plays an
important role for therapeutic applications. Indeed, protein/peptide delivery could overcome …

Design strategies for fluorescent proteins/mimics and their applications in biosensing and bioimaging

H Deng, S Yan, Y Huang, C Lei, Z Nie - TrAC Trends in Analytical …, 2020 - Elsevier
Fluorescent proteins (FPs) are powerful and fundamental tools in bio-analytical research,
ranging from tracking biological molecules to monitoring dynamic processes in living cells …

Advanced Nanomedicine for High-Risk HPV-Driven Head and Neck Cancer

Q Xu, Y Chen, Y Jin, Z Wang, H Dong, AM Kaufmann… - Viruses, 2022 - mdpi.com
The incidence of high-risk Human Papillomavirus (HR-HPV)-driven head and neck
squamous cell carcinoma (HNSCC) is on the rise globally. HR-HPV-driven HNSCC displays …

Design and in vitro delivery of HIV-1 multi-epitope DNA and peptide constructs using novel cell-penetrating peptides

S Davoodi, A Bolhassani, SM Sadat, S Irani - Biotechnology letters, 2019 - Springer
Objectives Developing an effective HIV vaccine that stimulates the humoral and cellular
immune responses is still challenging because of the diversity of HIV-1 virus, polymorphism …

Emerging Landscape of Supercharged Proteins and Peptides for Drug Delivery

L Wang, J Geng, H Wang - ACS Pharmacology & Translational …, 2024 - ACS Publications
Although groundbreaking biotechnological techniques such as gene editing have
significantly progressed, the effective and targeted transport of therapeutic agents into host …