γδ T cell effector functions: a blend of innate programming and acquired plasticity

M Bonneville, RL O'brien, WK Born - Nature Reviews Immunology, 2010 - nature.com
Abstract γδ T cells have several innate cell-like features that allow their early activation
following recognition of conserved stress-induced ligands. Here we review recent …

[HTML][HTML] Chronic inflammation and asthma

JR Murdoch, CM Lloyd - Mutation Research/Fundamental and Molecular …, 2010 - Elsevier
Allergic asthma is a complex and chronic inflammatory disorder which is associated with
airway hyper-responsiveness and tissue remodelling of the airway structure. Although …

Cross-presenting human γδ T cells induce robust CD8+ αβ T cell responses

M Brandes, K Willimann, G Bioley… - Proceedings of the …, 2009 - National Acad Sciences
γδ T cells are implicated in host defense against microbes and tumors but their mode of
function remains largely unresolved. Here, we have investigated the ability of activated …

Cellular immunity in ASFV responses

HH Takamatsu, MS Denyer, A Lacasta, CMA Stirling… - Virus research, 2013 - Elsevier
African swine fever virus (ASFV) infection usually results in an acute haemorrhagic disease
with a mortality rate approaching 100% in domestic pigs. However, pigs can survive …

Cytokine requirements for the differentiation and expansion of IL-17A–and IL-22–producing human Vγ2Vδ2 T cells

KJ Ness-Schwickerath, C Jin… - The Journal of Immunology, 2010 - journals.aai.org
Human γδ T cells expressing the Vγ2Vδ2 TCR play important roles in immune responses to
microbial pathogens by monitoring prenyl pyrophosphate isoprenoid metabolites. Most adult …

γδ-T cells: an unpolished sword in human anti-infection immunity

J Zheng, Y Liu, YL Lau, W Tu - Cellular & molecular immunology, 2013 - nature.com
Abstract γδ-T cells represent a small population of immune cells, but play an indispensable
role in host defenses against exogenous pathogens, immune surveillance of endogenous …

Human γδ T cells: a lymphoid lineage cell capable of professional phagocytosis

Y Wu, W Wu, WM Wong, E Ward… - The Journal of …, 2009 - journals.aai.org
Professional phagocytosis in mammals is considered to be performed exclusively by
myeloid cell types. In this study, we demonstrate, for the first time, that a mammalian …

The role of glia, mitochondria, and the immune system in glaucoma

G Tezel - Investigative ophthalmology & visual science, 2009 - iovs.arvojournals.org
April 25 and 26, 2008, in Fort Lauderdale, Florida. This conference series, funded by the
ARVO Foundation for Eye Research through a grant from Pfizer Ophthalmics, provides an …

Differentiation and functional plasticity of gamma-delta (γδ) T cells under homeostatic and disease conditions

S Giri, G Lal - Molecular Immunology, 2021 - Elsevier
Gamma-delta (γδ) T cells are a heterogeneous population of immune cells, which
constitute< 5% of total T cells in mice lymphoid tissue and human peripheral blood …

Comparative biology of γδ T cell function in humans, mice, and domestic animals

J Holderness, JF Hedges, A Ramstead… - Annu. Rev. Anim …, 2013 - annualreviews.org
γδ T cells are a functionally heterogeneous population and contribute to many early immune
responses. The majority of their activity is described in humans and mice, but the immune …