The application of scaffolding materials is believed to hold enormous potential for tissue
regeneration. Despite the widespread application and rapid advance of several tissue …

Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Recent advances indicate that periodontitis is driven by reciprocally reinforced interactions
between a dysbiotic microbiome and dysregulated inflammation. Inflammation is not only a …

Although the core concept of remyelination—based on the activation, migration, proliferation
and differentiation of CNS progenitors—has not changed over the past 20 years, our …

Regenerative capacity declines throughout evolution and with age. In this study, we asked
whether metabolic programs underlying regenerative capability might be conserved across …

In modern medicine, bone and dental loss and defects are common and widespread
morbidities, for which regenerative therapy has shown great promise. Mesenchymal stem …

Aging is a dynamic, time-dependent process that is characterized by a gradual accumulation
of cell damage. Continual functional decline in the intrinsic ability of living organisms to …

During aging, stromal functions are thought to be impaired, but little is known whether this
stems from changes of fibroblasts. Using population-and single-cell transcriptomics, as well …

A common hallmark of age‐dependent neurodegenerative diseases is an impairment of
adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β …

The establishment of an early pro-regenerative niche is crucial for tissue regeneration,.
Gasdermin D (GSDMD)-dependent pyroptosis accounts for the release of inflammatory …