In late 2020, after circulating for almost a year in the human population, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibited a major step change in its …

Abstract Since SARS-CoV-2 BA. 5 (Omicron) emerged and spread in 2022, Omicron
lineages have markedly diversified. Here we review the evolutionary trajectories and …

Despite vaccination and antiviral therapies, immunocompromised individuals are at risk for
prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but the …

Persistent SARS-CoV-2 infections may act as viral reservoirs that could seed future
outbreaks,,,–, give rise to highly divergent lineages,–and contribute to cases with post-acute …

As the COVID-19 pandemic has evolved during the past years, interactions between human
immune systems, rapidly mutating and selected SARS-CoV-2 viral variants, and effective …

Continued evolution and adaptation of SARS-CoV-2 has led to more transmissible and
immune-evasive variants with profound impacts on the course of the pandemic. Here I …

SARS-CoV-2 causes persistent infections in a subset of individuals, which is a major clinical
and public health problem that should be prioritised for further investigation for several …

Over three years' pandemic of 2019 novel coronavirus disease (COVID-19), multiple
variants and novel subvariants have emerged successively, outcompeted earlier variants …

This Lilliput explores the current epidemiological and virological arguments for a zoonotic
origin of the COVID‐19 pandemic. While the role of bats, pangolins and racoon dogs as viral …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was responsible for
the COVID-19 pandemic, efficiently spreads cell-to-cell through mechanisms facilitated by its …