Giardia duodenalis: biology and pathogenesis

RD Adam - Clinical microbiology reviews, 2021 - Am Soc Microbiol
Giardia duodenalis captured the attention of Leeuwenhoek in 1681 while he was examining
his own diarrheal stool, but, ironically, it did not really gain attention as a human pathogen …

A central role of the endoplasmic reticulum in the cell emerges from its functional contact sites with multiple organelles

C Almeida, MD Amaral - Cellular and Molecular Life Sciences, 2020 - Springer
Early eukaryotic cells emerged from the compartmentalization of metabolic processes into
specific organelles through the development of an endomembrane system (ES), a precursor …

Exosome Biogenesis in the Protozoa Parasite Giardia lamblia: A Model of Reduced Interorganellar Crosstalk

S Moyano, J Musso, C Feliziani, N Zamponi… - Cells, 2019 - mdpi.com
Extracellular vesicles (EVs) facilitate intercellular communication and are considered a
promising therapeutic tool for the treatment of infectious diseases. These vesicles involve …

Lactoferrin and lactoferricin endocytosis halt Giardia cell growth and prevent infective cyst production

LS Frontera, S Moyano, G Quassollo… - Scientific reports, 2018 - nature.com
Lactoferrin (LF) is an 80 KDa iron-binding glycoprotein that plays a significant role in the
innate immune system and is considered to be an important microbicide molecule. It has …

An in-depth exploration of the multifaceted roles of EVs in the context of pathogenic single-cell microorganisms

AS Feix, EZ Tabaie, AN Singh… - Microbiology and …, 2024 - Am Soc Microbiol
Extracellular vesicles (EVs) have been recognized throughout scientific communities as
potential vehicles of intercellular communication in both eukaryotes and prokaryotes …

Comparative proteomics of three Giardia lamblia strains: Investigation of antigenic variation in the post-genomic era

J Müller, S Braga, AC Uldry, M Heller, N Müller - Parasitology, 2020 - cambridge.org
Giardia lamblia is a causative agent of persistent diarrhoea widespread in regions with low
hygienic standards. Laboratory research is based on cloned lines issuing from various …

Sorting without a Golgi complex

MC Touz, N Zamponi - Traffic, 2017 - Wiley Online Library
The endoplasmic reticulum‐Golgi‐target organelle route is one of the most studied events
and has fascinated researchers for years. However, the conservative mechanism of protein …

Involvement of PRRSV NSP3 and NSP5 in the autophagy process

W Zhang, K Chen, Y Guo, Y Chen, X Liu - Virology journal, 2019 - Springer
Background Autophagy is an essential process in eukaryotic cells in which
autophagosomes form to deliver cellular organelles and long-lived proteins to lysosomes for …

The reduced ARF regulatory system in Giardia intestinalis pre-dates the transition to parasitism in the lineage Fornicata

SV Pipaliya, LA Thompson, JB Dacks - International Journal for …, 2021 - Elsevier
Giardia intestinalis is an enteric pathogen with an extremely modified membrane trafficking
system, lacking canonical compartments such as the Golgi, endosomes, and intermediate …

Symbiotic origin of eukaryotic nucleus: from cell body to neo-energide

F Baluška, S Lyons - Concepts in Cell Biology-History and Evolution, 2018 - Springer
Several aspects of the eukaryotic cell suggest that the nucleus is of symbiotic origin. The
nucleus forms, via its perinuclear structures, the primary eukaryotic agent known also as the …