The muscular dystrophies are rare orphan diseases, characterized by progressive muscle
weakness: the most common and well known is Duchenne muscular dystrophy which affects …

Recent years have seen tremendous progress towards therapy of many previously incurable
neuromuscular diseases. This new context has acted as a driving force for the development …

Skeletal muscle has the remarkable ability to regenerate. However, with age and disease
muscle strength and function decline. Myofiber size, which is affected by injury and disease …

Objective The aim of this study was to describe Duchenne muscular dystrophy (DMD)
disease progression in the lower extremity muscles over 12 months using quantitative …

Due to its exceptional sensitivity to soft tissues, MRI has been extensively utilized to assess
anatomical muscle parameters such as muscle volume and cross‐sectional area …

Successful muscle regeneration relies on the interplay of multiple cell populations. However,
the signals required for this coordinated intercellular crosstalk remain largely unknown …

Fibro-adipogenic progenitors (FAPs) are key regulators of skeletal muscle regeneration and
homeostasis. However, dysregulation of these cells leads to fibro-fatty infiltration across …

There is an unmet need to identify biomarkers sensitive to change in rare, slowly
progressive neuromuscular diseases. Quantitative magnetic resonance imaging (MRI) of …

In muscular dystrophies quantitative muscle MRI (qMRI) detects disease progression more
sensitively than clinical scores. This prospective one year observational study compared …

Objective We studied the potential of quantitative MRI (qMRI) as a surrogate endpoint in
Duchenne muscular dystrophy by assessing the additive predictive value of vastus lateralis …