Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics
currently in clinical use and only a few novel drugs in the pipeline. Understanding the …

Gram-negative bacteria and their complex cell envelope, which comprises an outer
membrane and an inner membrane, are an important and attractive system for studying the …

Small RNAs are ubiquitously present regulators in all kingdoms of life. Most bacterial and
archaeal small RNAs (sRNAs) act by antisense mechanisms on multiple target mRNAs …

The IntaRNA algorithm enables fast and accurate prediction of RNA–RNA hybrids by
incorporating seed constraints and interaction site accessibility. Here, we introduce …

Small RNA regulators (sRNAs) have been identified in a wide range of bacteria and found to
play critical regulatory roles in many processes. The major families of sRNAs include true …

Protein concentrations are set by a complex interplay between gene-specific regulatory
processes and systemic factors, including cell volume and shared gene expression …

Fluoroquinolones are an important class of wide‐spectrum antibacterial agents. The first
quinolone described was nalidixic acid, which showed a narrow spectrum of activity. The …

Motivation: During the last few years, several new small regulatory RNAs (sRNAs) have
been discovered in bacteria. Most of them act as post-transcriptional regulators by base …

Gram-negative bacteria depend on their cell membranes for survival and environmental
adaptation. They contain two membranes, one of which is the outer membrane (OM), which …

Abstract Motivation: Regulatory RNAs often unfold their action via RNA-RNA interaction.
Transcriptional gene silencing by means of siRNAs and miRNA as well as snoRNA directed …