STRAIGHT-IN enables high-throughput targeting of large DNA payloads in human pluripotent stem cells
A Blanch-Asensio, C Grandela, KO Brandão… - Cell Reports …, 2022 - cell.com
Inserting large DNA payloads (> 10 kb) into specific genomic sites of mammalian cells
remains challenging. Applications ranging from synthetic biology to evaluating the …
remains challenging. Applications ranging from synthetic biology to evaluating the …
Injection of IK1 through dynamic clamp can make all the difference in patch-clamp studies on hiPSC-derived cardiomyocytes
AO Verkerk, R Wilders - Frontiers in physiology, 2023 - frontiersin.org
Human-induced stem cell-derived cardiomyocytes (hiPSC-CMs) are a valuable tool for
studying development, pharmacology, and (inherited) arrhythmias. Unfortunately, hiPSC …
studying development, pharmacology, and (inherited) arrhythmias. Unfortunately, hiPSC …
Deciphering common long QT syndrome using CRISPR/Cas9 in Human-induced pluripotent stem cell-derived cardiomyocytes
Y Song, Z Zheng, J Lian - Frontiers in cardiovascular medicine, 2022 - frontiersin.org
From carrying potentially pathogenic genes to severe clinical phenotypes, the basic
research in the inherited cardiac ion channel disease such as long QT syndrome (LQTS) …
research in the inherited cardiac ion channel disease such as long QT syndrome (LQTS) …
The Advantages, Challenges, and Future of Human-Induced Pluripotent Stem Cell Lines in Type 2 Long QT Syndrome
D Cai, Z Zheng, X Jin, Y Fu, L Cen, J Ye, Y Song… - Journal of …, 2023 - Springer
Type 2 long QT syndrome (LQT2) is the second most common subtype of long QT syndrome
and is caused by mutations in KCHN2 encoding the rapidly activating delayed rectifier …
and is caused by mutations in KCHN2 encoding the rapidly activating delayed rectifier …
[HTML][HTML] Modeling incomplete penetrance in arrhythmogenic cardiomyopathy by human induced pluripotent stem cell derived cardiomyocytes
M De Bortoli, V Meraviglia, K Mackova… - Computational and …, 2023 - Elsevier
Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) are commonly
used to model arrhythmogenic cardiomyopathy (ACM), a heritable cardiac disease …
used to model arrhythmogenic cardiomyopathy (ACM), a heritable cardiac disease …