The onset of amyloidogenic diseases is associated with the misfolding and aggregation of
proteins. Despite extensive research, no effective therapeutics are yet available to treat …

Type 2 diabetes (T2D) is a chronic metabolic disease characterized by insulin resistance
and a progressive loss of pancreatic islet β-cell mass, which leads to insufficient secretion of …

The Omicron lineage of SARS-CoV-2, which was first reported in November 2021, has
spread globally and become dominant, splitting into several sublineages. Experiments have …

COVID-19 has emerged as the most serious international pandemic in early 2020 and the
lack of comprehensive knowledge in the recognition and transmission mechanisms of this …

At present, the calculated binding free energy obtained using the molecular
mechanics/Poisson-Boltzmann (Generalized-Born) surface area (MM/PB (GB) SA) method is …

The design of small molecule inhibitors that target the programmed death ligand-1 (PD-L1)
is a forefront issue in immune checkpoint blocking therapy. Small-molecule inhibitors have …

DNA methylation as an important epigenetic marker, has gained attention for the
significance of three oxidative modifications (hydroxymethyl-C (hmC), formyl-C (fC), and …

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with
exposure to repetitive head impacts, and it is neuropathologically defined as the …

Amyloid aggregation is at the molecular basis of neurodegeneration and provides toxic
species which trigger the progression of the disease. Hence, there is an urgent need to …

The formation of amyloid fibrils by α-synuclein (αS) protein inside the Lewy bodies and Lewy
neurites is the prominent pathological hallmark of Parkinson's disease (PD). The fibrillation …