Distinct metabolic states guide maturation of inflammatory and tolerogenic dendritic cells

J Adamik, PV Munson, FJ Hartmann… - Nature …, 2022 - nature.com
Cellular metabolism underpins immune cell functionality, yet our understanding of metabolic
influences in human dendritic cell biology and their ability to orchestrate immune responses …

The advance anticancer role of polymeric core‐shell ZnO nanoparticles containing oxaliplatin in colorectal cancer

N Alavi, P Maghami, A Fani Pakdel… - … of Biochemical and …, 2023 - Wiley Online Library
We evaluated the activity of core‐shell ZnO nanoparticles (ZnO‐NPs@ polymer shell)
containing Oxaliplatin via polymerization through in vitro studies and in vivo mouse models …

KCNK3 inhibits proliferation and glucose metabolism of lung adenocarcinoma via activation of AMPK-TXNIP pathway

G Lin, L Lin, H Lin, W Chen, L Chen, X Chen… - Cell Death …, 2022 - nature.com
Non-small cell lung cancer (NSCLC) is a primary histological subtype of lung cancer with
increased morbidity and mortality. K+ channels have been revealed to be involved in …

Auraptene-induced cytotoxic effects in acute myeloid leukemia cell lines

M Ghorbani, M Soukhtanloo, AS Farrokhi… - Medical Oncology, 2023 - Springer
Acute myeloid leukemia is one of the most commonly identified hematological malignancies
with poor prognosis. This research was planned to identify the cytotoxic effects of Auraptene …

CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling

S Yu, Q Hu, K Fan, C Yang, Y Gao - Journal of Cell Communication and …, 2021 - Springer
The function of Casein kinase 2 beta (CSNK2B) in human malignancies has drawn
increasing attention in recent years. However, its role in colorectal cancer (CRC) remains …

Overfit deep neural network for predicting drug-target interactions

X Xiaolin, L Xiaozhi, H Guoping, L Hongwei, G Jinkuo… - Iscience, 2023 - cell.com
Drug-target interactions (DTIs) prediction is an important step in drug discovery. As
traditional biological experiments or high-throughput screening are high cost and time …

Selective AMPK activator leads to unfolded protein response downregulation and induces breast cancer cell death and autophagy

ALN Mello, FS Sagrillo, AG de Souza, ARP Costa… - Life Sciences, 2021 - Elsevier
Aims AMPK plays a critical role regulating cell metabolism, growth and survival. Interfering
with this enzyme activity has been extensively studied as putative mechanism for cancer …

KIF18B as a regulator in microtubule movement accelerates tumor progression and triggers poor outcome in lung adenocarcinoma

Z Ji, X Pan, Y Shang, DT Ni, FL Wu - Tissue and Cell, 2019 - Elsevier
KIF18B is involved in several tumor progression and exerts critical effects on microtubule
growth during mitosis, but its role in lung adenocarcinoma still remains rare. Hence, we …

Dorsomorphin attenuates ABCG2-mediated multidrug resistance in colorectal cancer

XP Li, LQ Cao, ZZ Yu, K He, PB Ding, JS Li… - Frontiers in …, 2024 - frontiersin.org
Colorectal cancer is a common malignant tumor with high mortality, for which chemotherapy
resistance is one of the main reasons. The high expression of ABCG2 in the cancer cells …

[HTML][HTML] Inhibition of angiotensin II type 1 receptor by candesartan reduces tumor growth and ameliorates fibrosis in colorectal cancer

E Tabatabai, M Khazaei, F Asgharzadeh, SE Nazari… - Excli Journal, 2021 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is an important cause of cancer-related mortality. Aberrant
activation of the renin-angiotensin system (RAS) is reported to be associated with poor …