Biological activity of dihydropyrimidinone (DHPM) derivatives: A systematic review

LHS Matos, FT Masson, LA Simeoni… - European journal of …, 2018 - Elsevier
Dihydropyrimidinones are heterocycles with a pyrimidine moiety in the ring nucleus, which,
in recent decades, have aroused interest in medicinal chemistry due to alleged versatile …

Synthesis of dihydropyrimidinones via multicomponent reaction route over acid functionalized Metal-Organic framework catalysts

B Krishna, S Payra, S Roy - Journal of Colloid and Interface Science, 2022 - Elsevier
Multi component reactions over heterogeneous solid acid catalysts are extremely important
owing to easy separation, amenable recycling, and prospective scaling up of the process …

Recent advances in the synthesis of C-5-substituted analogs of 3, 4-dihydropyrimidin-2-ones: a review

SK Rathwa, MS Vasava, MN Bhoi… - Synthetic …, 2018 - Taylor & Francis
Dihydropyrimidin-2-ones act as a versatile scaffold in organic synthesis, which serves as a
significant template for the development of various therapeutic agents and shows a wide …

[HTML][HTML] The Evaluation of DHPMs as Biotoxic Agents on Pathogen Bacterial Membranes

B Gawdzik, P Kowalczyk, D Koszelewski, A Brodzka… - Membranes, 2022 - mdpi.com
Herein, we present biological studies on 3, 4-dihydropyrimidin-2 (1H)-ones (DHPMs)
obtained via Biginelli reaction catalyzed by NH4Cl under solvent-free conditions. Until now …

Synthesis of 4, 4-disubstituted 3, 4-dihydropyrimidin-2 (1H)-ones and-thiones, the corresponding products of Biginelli reaction using ketone, and their antiproliferative …

Y Nishimura, H Kikuchi, T Kubo, R Arai… - Chemical and …, 2022 - jstage.jst.go.jp
An efficient synthetic method for novel 4, 4-disubstituted 3, 4-dihydropyrimidin-2 (1H)-ones 5
and-thiones 6 was developed. The cyclocondensation reaction of O-methylisourea …

Ultrasound-assisted one-pot synthesis of tetrahydropyrimidne derivatives through biginelli condensation: A catalyst free green chemistry approach

A Patel, J Shah, K Patel, K Patel, H Patel… - Letters in Organic …, 2021 - ingentaconnect.com
Letters in Organic Chemistry Page 1 Letters in Organic Chemistry ImpactFactor:0.723 ISSN:
1570-1786 eISSN: 1875-6255 BENTHAM SCIENCE Send Orders for Reprints to reprints@benthamscience.net …

Synthesis of novel adamantane-containing dihydropyrimidines utilizing Biginelli condensation reaction

M Abkar Aras, A Moshtaghi Zonouz - Journal of Sulfur Chemistry, 2023 - Taylor & Francis
Novel dihydropyrimidines incorporating an adamantane motif have been synthesized using
a three-component Biginelli reaction of adamantane-containing β-keto amide N-1 …

[HTML][HTML] Synthesis, in vitro evaluation and QSAR modelling of potential antitumoral 3, 4-dihydropyrimidin-2-(1H)-thiones

M Matias, G Campos, AO Santos, A Falcão… - Arabian Journal of …, 2019 - Elsevier
Abstract A series of 3, 4-dihydropyrimidin-2-(1H)-thiones (1–22) was synthesized through
the Biginelli reaction in order to find novel anticancer drug candidates based on the structure …

The role of carboxylic acid contents in calcium-based metal-organic frameworks for the enhancement of Biginelli reaction

RM Abdelhameed, M El-Shahat - Journal of Molecular Structure, 2024 - Elsevier
Metal-organic frameworks (MOFs) can carry different functional groups such as COOH, NH
2, and SO 3 H. The most commonly used functional group was COOH due to its Brønsted …

One-pot synthesis of thioxo-tetrahydropyrimidine derivatives as potent β-glucuronidase inhibitor, biological evaluation, molecular docking and molecular dynamics …

A Iraji, A Nouri, N Edraki, S Pirhadi… - Bioorganic & Medicinal …, 2020 - Elsevier
Abstract A series of N, N-diethyl phenyl thioxo-tetrahydropyrimidine carboxamide have been
synthesized and investigated for their β-glucuronidase inhibitory activities. All molecules …