Heterotrimeric G proteins are the core upstream elements that transduce and amplify the
cellular signals from G protein–coupled receptors (GPCRs) to intracellular effectors. GPCRs …

Simple Summary Uveal melanoma is a deadly form of eye cancer with a high rate of
metastasis. Once metastasis occurs, patients are often left with a short survival time, since …

The potent and selective Gq protein inhibitor depsipeptide FR900359 (FR), originally
discovered as the product of an uncultivable plant endosymbiont, is synthesized by a …

Transmembrane signals initiated by a range of extracellular stimuli converge on members of
the Gq family of heterotrimeric G proteins, which relay these signals in target cells. Gq family …

Noncanonical G protein activation and inactivation, particularly for the Gαi/s protein
subfamilies, have long been a focus of chemical research. Combinatorial libraries were …

Heterotrimeric G proteins are molecular switches in GPCR signaling pathways and regulate
a plethora of physiological and pathological processes. GPCRs are efficient drug targets …

G proteins are key mediators of G protein‐coupled receptor (GPCR) signaling, facilitating a
plethora of important physiological processes. The role of G proteins is much less …

Covering: up to April 2021 The bacterial cyclic depsipeptides FR900359 (FR) and YM-
254890 (YM) were shown to selectively inhibit Gαq proteins with high potency and selectivity …

G proteins represent intracellular switches that transduce signals relayed from G protein-
coupled receptors. The structurally related macrocyclic depsipeptides FR900359 (FR) and …

ABSTRACT Murraya koenigii (Linn.) Spreng, commonly known as curry leaf tree, is popular
as a condiment and spice among Asian countries. Ethnobotanical studies suggest that …