Plasmodium sporozoites are the product of a complex developmental process in the
mosquito vector and are destined to infect the mammalian liver. Attention has been drawn to …

In malaria, the red blood cell-infectious form of the Plasmodium parasite causes illness and
the possible death of infected hosts. The initial infection in the liver caused by the mosquito …

Intracellular malaria parasites require lipids for growth and replication. They possess a
prokaryotic type II fatty acid synthesis (FAS II) pathway that localizes to the apicoplast plastid …

The causative agent of malaria, Plasmodium, replicates inside a membrane-bound
parasitophorous vacuole (PV), which shields this intracellular parasite from the cytosol of the …

Apicomplexan parasites are responsible for high impact human diseases such as malaria,
toxoplasmosis, and cryptosporidiosis. These obligate intracellular pathogens are dependent …

Summary The Chinese herb Dichroa febrifuga has traditionally treated malaria-associated
fever. Its active component febrifugine (FF) and derivatives such as halofuginone (HF) are …

Plasmodium parasites have a complex life cycle alternating between a mosquito and a
vertebrate host. Following the bite of an Anopheles female mosquito, Plasmodium …

Introduction Eradication of malaria remains one of the main aims of medicine. Despite
progress in malaria treatment, mortality rate remains high, especially in the poorest parts of …

Highlights•Malaria remains a killer disease and drug resistance poses a growing
problem.•Aminoacyl tRNA synthetases (aaRSs) are essential housekeeping …

The life cycles of apicomplexan parasites such as Plasmodium spp. and Toxoplasma gondii
are complex, consisting of proliferative and latent stages within multiple hosts. Dramatic …