Diabetic cataracts: mechanisms and management

IG Obrosova, SSM Chung… - … /metabolism research and …, 2010 - Wiley Online Library
Diabetes mellitus is associated with a 5‐fold higher prevalence of cataracts, which remains
a major cause of blindness in the world. Typical diabetic cataracts contain cortical and/or …

Role of haeme oxygenase‐1 in resolution of oxidative stress‐related pathologies: focus on cardiovascular, lung, neurological and kidney disorders

DD Haines, I Lekli, P Teissier, I Bak… - Acta …, 2012 - Wiley Online Library
The present review examines the role of the cytoprotective enzyme haeme oxygenase‐1
(HO‐1) in adaptive responses to inflammatory disease and explores strategies for its clinical …

Reactive oxygen species and the aging eye: Specific role of metabolically active mitochondria in maintaining lens function and in the initiation of the oxidation-induced …

MA Babizhayev, YE Yegorov - American journal of therapeutics, 2016 - journals.lww.com
The aging eye appears to be at considerable risk from oxidative stress. A great deal of
research indicates that dysfunctional mitochondria are the primary site of reactive oxygen …

[HTML][HTML] Epigallocatechin gallate protects against oxidative stress-induced mitochondria-dependent apoptosis in human lens epithelial cells

K Yao, PP Ye, L Zhang, J Tan, XJ Tang… - Molecular vision, 2008 - ncbi.nlm.nih.gov
Purpose Oxidative stress has long been recognized as an important mediator of apoptosis in
lens epithelial cells and also plays an important role in the pathogenesis of cataracts.(-) …

[HTML][HTML] Generation of reactive oxygen species in the anterior eye segment. Synergistic codrugs of N-acetylcarnosine lubricant eye drops and mitochondria-targeted …

MA Babizhayev - BBA clinical, 2016 - Elsevier
Senile cataract is a clouding of the lens in the aging eye leading to a decrease in vision.
Symptoms may include faded colors, blurry vision, halos around light, trouble with bright …

Mitochondria induce oxidative stress, generation of reactive oxygen species and redox state unbalance of the eye lens leading to human cataract formation: disruption …

MA Babizhayev - Cell Biochemistry and Function, 2011 - Wiley Online Library
The aging eye appears to be at considerable risk from oxidative stress. Lipid peroxidation
(LPO) is one of the mechanisms of cataractogenesis, initiated by enhanced promotion of …

Altered ubiquitin causes perturbed calcium homeostasis, hyperactivation of calpain, dysregulated differentiation, and cataract

K Liu, L Lyu, D Chin, J Gao, X Sun… - Proceedings of the …, 2015 - National Acad Sciences
Although the ocular lens shares many features with other tissues, it is unique in that it retains
its cells throughout life, making it ideal for studies of differentiation/development …

Heme oxygenase-1–related carbon monoxide and flavonoids in ischemic/reperfused rat retina

ME Szabo, E Gallyas, I Bak… - … & visual science, 2004 - iovs.arvojournals.org
purpose. There is increasing evidence to show cytoprotective effects of various flavonoid-
rich extracts and the tissue-protective capacity of flavonoid-rich extract of sour cherry is due …

Green Tea (Camellia sinensis) Protects against Selenite-Induced Oxidative Stress in Experimental Cataractogenesis

SK Gupta, N Halder, S Srivastava, D Trivedi… - Ophthalmic …, 2002 - karger.com
Cataract is the leading cause of blindness worldwide. It is a multifactorial disease primarily
associated with oxidative stress produced by free radicals. The protection offered by various …

The role of the lens actin cytoskeleton in fiber cell elongation and differentiation

PV Rao, R Maddala - Seminars in cell & developmental biology, 2006 - Elsevier
The vertebrate ocular lens is a fascinating and unique transparent tissue that grows
continuously throughout life. During the process of differentiation into fiber cells, lens …