Origins and challenges of viral dark matter
SR Krishnamurthy, D Wang - Virus research, 2017 - Elsevier
The accurate classification of viral dark matter–metagenomic sequences that originate from
viruses but do not align to any reference virus sequences–is one of the major obstacles in …
viruses but do not align to any reference virus sequences–is one of the major obstacles in …
Targeting HIF-2α in the tumor microenvironment: redefining the role of HIF-2α for solid cancer therapy
Simple Summary Hypoxia is defined as the inadequate supply of oxygen in tissues. Regions
of acute and chronic hypoxia are a universal feature of the tumor microenvironment and a …
of acute and chronic hypoxia are a universal feature of the tumor microenvironment and a …
Codon usage is an important determinant of gene expression levels largely through its effects on transcription
Codon usage biases are found in all eukaryotic and prokaryotic genomes, and preferred
codons are more frequently used in highly expressed genes. The effects of codon usage on …
codons are more frequently used in highly expressed genes. The effects of codon usage on …
Genome-wide role of codon usage on transcription and identification of potential regulators
Codon usage bias is a fundamental feature of all genomes and plays an important role in
determining gene expression levels. The codon usage was thought to influence gene …
determining gene expression levels. The codon usage was thought to influence gene …
Codon usage regulates human KRAS expression at both transcriptional and translational levels
KRAS and HRAS are highly homologous oncogenic Ras GTPase family members that are
mutated in a wide spectrum of human cancers. Despite having high amino acid identity …
mutated in a wide spectrum of human cancers. Despite having high amino acid identity …
Codon usage biases co-evolve with transcription termination machinery to suppress premature cleavage and polyadenylation
Z Zhou, Y Dang, M Zhou, H Yuan, Y Liu - Elife, 2018 - elifesciences.org
Codon usage biases are found in all genomes and influence protein expression levels. The
codon usage effect on protein expression was thought to be mainly due to its impact on …
codon usage effect on protein expression was thought to be mainly due to its impact on …
Screening thousands of transcribed coding and non-coding regions reveals sequence determinants of RNA polymerase II elongation potential
Precise regulation of transcription by RNA polymerase II (RNAPII) is critical for organismal
growth and development. However, what determines whether an engaged RNAPII will …
growth and development. However, what determines whether an engaged RNAPII will …
Hypermethylation of PDX1, EN2, and MSX1 predicts the prognosis of colorectal cancer
Y Lee, SH Dho, J Lee, JH Hwang, M Kim… - … & molecular medicine, 2022 - nature.com
Despite numerous observations regarding the relationship between DNA methylation
changes and cancer progression, only a few genes have been verified as diagnostic …
changes and cancer progression, only a few genes have been verified as diagnostic …
Improving DNA vaccine performance through vector design
JA Williams - Current gene therapy, 2014 - ingentaconnect.com
DNA vaccines are a rapidly deployed next generation vaccination platform for treatment of
human and animal disease. DNA delivery devices, such as electroporation and needle free …
human and animal disease. DNA delivery devices, such as electroporation and needle free …
Evolution and diversity of nucleotide and dinucleotide composition in poxviruses
Poxviruses (family Poxviridae) have long dsDNA genomes and infect a wide range of hosts,
including insects, birds, reptiles and mammals. These viruses have substantial incidence …
including insects, birds, reptiles and mammals. These viruses have substantial incidence …