Endocytosis and intracellular trafficking as gateways for nanomedicine delivery: opportunities and challenges
R Duncan, SCW Richardson - Molecular pharmaceutics, 2012 - ACS Publications
More than 40 nanomedicines are already in routine clinical use with a growing number
following in preclinical and clinical development. The therapeutic objectives are often …
following in preclinical and clinical development. The therapeutic objectives are often …
Alkyne-azide “click” chemistry in designing nanocarriers for applications in biology
The alkyne-azide cycloaddition, popularly known as the “click” reaction, has been
extensively exploited in molecule/macromolecule build-up, and has offered tremendous …
extensively exploited in molecule/macromolecule build-up, and has offered tremendous …
[HTML][HTML] Disarmed anthrax toxin delivers antisense oligonucleotides and siRNA with high efficiency and low toxicity
PDR Dyer, TR Shepherd, AS Gollings… - Journal of Controlled …, 2015 - Elsevier
Inefficient cytosolic delivery and vector toxicity contribute to the limited use of antisense
oligonucleotides (ASOs) and siRNA as therapeutics. As anthrax toxin (Atx) accesses the …
oligonucleotides (ASOs) and siRNA as therapeutics. As anthrax toxin (Atx) accesses the …
Leishmania aethiopica cell‐to‐cell spreading involves caspase‐3, AkT, and NF‐κB but not PKC‐δ activation and involves uptake of LAMP‐1‐positive bodies …
M Ranatunga, R Rai, SCW Richardson… - The FEBS …, 2020 - Wiley Online Library
Development of human leishmaniasis is dependent on the ability of intracellular Leishmania
parasites to spread and enter macrophages. The mechanism through which free …
parasites to spread and enter macrophages. The mechanism through which free …
Green fluorescent protein (GFP): is seeing believing and is that enough?
Intracellular compartmentalisation is a significant barrier to the successful nucleocytosolic
delivery of biologics. The endocytic system has been shown to be responsible for …
delivery of biologics. The endocytic system has been shown to be responsible for …
[引用][C] Click chemistry in nano drug delivery system and its applications in biology
N Majumder - IJRPC, 2015