Cell-surface heparan sulfate proteoglycans as multifunctional integrators of signaling in cancer
Proteoglycans (PGs) represent a large proportion of the components that constitute the
extracellular matrix (ECM). They are a diverse group of glycoproteins characterized by a …
extracellular matrix (ECM). They are a diverse group of glycoproteins characterized by a …
[HTML][HTML] Discrete dynamic network modeling of oncogenic signaling: Mechanistic insights for personalized treatment of cancer
Targeted drugs disrupting proteins that are dysregulated in cancer have emerged as
promising treatments because of their specificity to cancer cell aberrations and thus their …
promising treatments because of their specificity to cancer cell aberrations and thus their …
Hybrid epithelial–mesenchymal phenotypes are controlled by microenvironmental factors
G Selvaggio, S Canato, A Pawar, PT Monteiro… - Cancer research, 2020 - AACR
Epithelial-to-mesenchymal transition (EMT) has been associated with cancer cell
heterogeneity, plasticity, and metastasis. However, the extrinsic signals supervising these …
heterogeneity, plasticity, and metastasis. However, the extrinsic signals supervising these …
[HTML][HTML] Revisiting epithelial carcinogenesis
LF Méndez-López - International Journal of Molecular Sciences, 2022 - mdpi.com
The origin of cancer remains one of the most important enigmas in modern biology. This
paper presents a hypothesis for the origin of carcinomas in which cellular aging and …
paper presents a hypothesis for the origin of carcinomas in which cellular aging and …
[HTML][HTML] Landscape and kinetic path quantify critical transitions in epithelial-mesenchymal transition
Abstract Epithelial-mesenchymal transition (EMT), a basic developmental process that might
promote cancer metastasis, has been studied from various perspectives. Recently, the early …
promote cancer metastasis, has been studied from various perspectives. Recently, the early …
Towards control of cellular decision-making networks in the epithelial-to-mesenchymal transition
We present the epithelial-to-mesenchymal transition (EMT) from two perspectives:
experimental/technological and theoretical. We review the state of the current understanding …
experimental/technological and theoretical. We review the state of the current understanding …
[HTML][HTML] Target control in logical models using the domain of influence of nodes
Dynamical models of biomolecular networks are successfully used to understand the
mechanisms underlying complex diseases and to design therapeutic strategies. Network …
mechanisms underlying complex diseases and to design therapeutic strategies. Network …
[HTML][HTML] A network modeling approach to elucidate drug resistance mechanisms and predict combinatorial drug treatments in breast cancer
Background Mechanistic models of within-cell signal transduction networks can explain how
these networks integrate internal and external inputs to give rise to the appropriate cellular …
these networks integrate internal and external inputs to give rise to the appropriate cellular …
[HTML][HTML] Leveraging quantum computing for dynamic analyses of logical networks in systems biology
The dynamics of cellular mechanisms can be investigated through the analysis of networks.
One of the simplest but most popular modeling strategies involves logic-based models …
One of the simplest but most popular modeling strategies involves logic-based models …
[HTML][HTML] A computational model of the endothelial to mesenchymal transition
Endothelial cells (ECs) form the lining of lymph and blood vessels. Changes in tissue
requirements or wounds may cause ECs to behave as tip or stalk cells. Alternatively, they …
requirements or wounds may cause ECs to behave as tip or stalk cells. Alternatively, they …