Metastatic dissemination of solid tumors, a leading cause of cancer-related mortality,
underscores the urgent need for enhanced insights into the molecular and cellular …

The management of non-small cell lung cancer (NSCLC) has changed significantly with the
discovery of specific drug targets. These drugs have helped transform patient care and …

We report a comprehensive proteogenomics analysis, including whole-genome sequencing,
RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 …

Low‐grade serous ovarian carcinoma (LGSOC) is associated with a poor response to
existing chemotherapy, highlighting the need to perform comprehensive genomic analysis …

The RAS-regulated RAF–MEK1/2–ERK1/2 pathway promotes cell proliferation and survival
and RAS and BRAF proteins are commonly mutated in cancer. This has fuelled the …

Abstract pLGGs are a group of tumors for which the era of molecular diagnostics has truly
shifted treatment paradigms and patient care. The discovery that this group of tumors is …

Low grade gliomas (LGGs) are the most common type of brain tumors diagnosed in children.
The presentation of intracranial tumors in pediatric patients is varied and diverse. The early …

Background Pediatric low-grade glioma (pLGG) is the most common childhood brain tumor.
Many patients with unresectable or recurrent/refractory tumors have significant lifelong …

BRAF (alternately referred to as v-raf murine sarcoma viral oncogene homolog B1) is a proto-
oncogene involved in the mitogen-activated protein kinase (MAPK) pathway. BRAF …

Abstract Purpose of Review Over the last years, our understanding of the molecular biology
of pediatric brain tumors has vastly improved. This has led to more narrowly defined …