Biological aging is an inevitable and independent risk factor for a wide array of chronic
diseases including cardiovascular and metabolic diseases. Ample evidence has established …

Despite clinical and scientific advancements, heart failure is the major cause of morbidity
and mortality worldwide. Both mitochondrial dysfunction and inflammation contribute to the …

Mitochondrial morphology, which is controlled by mitochondrial fission and fusion, is an
important regulator of the thermogenic capacity of brown adipocytes. Adipose-specific …

TCR stimulation triggers Ca2+ signals that are critical for T cell function and immunity.
Several pore-forming α and auxiliary β subunits of voltage-gated Ca2+ channels (VGCC) …

Sterol regulatory-element binding proteins (SREBPs) are classical regulators of cellular lipid
metabolism in the kidney and other tissues. SREBPs are currently recognized as versatile …

The important roles of mitochondrial function and dysfunction in the process of
neurodegeneration are widely acknowledged. Retinal ganglion cells (RGCs) appear to be a …

HIV infection and antiretroviral therapy alter mitochondrial function, which can progressively
lead to mitochondrial damage and accelerated aging. The interaction between persistent …

Peroxisomes are highly dynamic, oxidative organelles with key metabolic functions in
cellular lipid metabolism, such as the β-oxidation of fatty acids and the synthesis of myelin …

Transmembrane proteins (TMEMs) are integral proteins that span biological membranes.
TMEMs function as cellular membrane gates by modifying their conformation to control the …

Abstract Transmembrane protein 135 (TMEM135) is thought to participate in the cellular
response to increased intracellular lipids yet no defined molecular function for TMEM135 in …