Incidence of narcolepsy after H1N1 influenza and vaccinations: systematic review and meta-analysis
TO Sarkanen, APE Alakuijala, YA Dauvilliers… - Sleep medicine …, 2018 - Elsevier
An increased incidence of narcolepsy was seen in many countries after the pandemic H1N1
influenza vaccination campaign in 2009–2010. The H1N1 vaccine–narcolepsy connection is …
influenza vaccination campaign in 2009–2010. The H1N1 vaccine–narcolepsy connection is …
Development and evaluation of AS03, an Adjuvant System containing α-tocopherol and squalene in an oil-in-water emulsion
N Garçon, DW Vaughn… - Expert review of …, 2012 - Taylor & Francis
AS03 is an Adjuvant System composed of α-tocopherol, squalene and polysorbate 80 in an
oil-in-water emulsion. In various nonclinical and clinical studies, high levels of antigen …
oil-in-water emulsion. In various nonclinical and clinical studies, high levels of antigen …
Epigenetic silencing of selected hypothalamic neuropeptides in narcolepsy with cataplexy
Narcolepsy with cataplexy is a sleep disorder caused by deficiency in the hypothalamic
neuropeptide hypocretin/orexin (HCRT), unanimously believed to result from autoimmune …
neuropeptide hypocretin/orexin (HCRT), unanimously believed to result from autoimmune …
AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland
Background Narcolepsy is a chronic sleep disorder with strong genetic predisposition
causing excessive daytime sleepiness and cataplexy. A sudden increase in childhood …
causing excessive daytime sleepiness and cataplexy. A sudden increase in childhood …
Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China
Objective: Narcolepsy is caused by the loss of hypocretin/orexin neurons in the
hypothalamus, which is likely the result of an autoimmune process. Recently, concern has …
hypothalamus, which is likely the result of an autoimmune process. Recently, concern has …
Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2
SS Ahmed, W Volkmuth, J Duca, L Corti… - Science translational …, 2015 - science.org
The sleep disorder narcolepsy is linked to the HLA-DQB1* 0602 haplotype and
dysregulation of the hypocretin ligand-hypocretin receptor pathway. Narcolepsy was …
dysregulation of the hypocretin ligand-hypocretin receptor pathway. Narcolepsy was …
Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland
M Partinen, O Saarenpää-Heikkilä, I Ilveskoski… - PloS one, 2012 - journals.plos.org
Background Narcolepsy is a rare neurological sleep disorder especially in children who are
younger than 10 years. In the beginning of 2010, an exceptionally large number of Finnish …
younger than 10 years. In the beginning of 2010, an exceptionally large number of Finnish …
Risk of narcolepsy in children and young people receiving AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine: retrospective analysis
Objective To evaluate the risk of narcolepsy in children and adolescents in England targeted
for vaccination with ASO3 adjuvanted pandemic A/H1N1 2009 vaccine (Pandemrix) from …
for vaccination with ASO3 adjuvanted pandemic A/H1N1 2009 vaccine (Pandemrix) from …
The incidence of narcolepsy in Europe: before, during, and after the influenza A (H1N1) pdm09 pandemic and vaccination campaigns
L Wijnans, C Lecomte, C de Vries, D Weibel… - Vaccine, 2013 - Elsevier
BACKGROUND: In August 2010 reports of a possible association between exposure to
AS03 adjuvanted pandemic A (H1N1) pdm09 vaccine and occurrence of narcolepsy in …
AS03 adjuvanted pandemic A (H1N1) pdm09 vaccine and occurrence of narcolepsy in …