The power of representation: Statistical analysis of diversity in US Alzheimer's disease genetics data
D Xue, EE Blue, MP Conomos… - Alzheimer's & Dementia …, 2024 - Wiley Online Library
INTRODUCTION Alzheimer's disease (AD) is a complex disease influenced by genetics and
environment. More than 75 susceptibility loci have been linked to late‐onset AD, but most of …
environment. More than 75 susceptibility loci have been linked to late‐onset AD, but most of …
Genetics and biomarkers of Alzheimer's disease in Asian populations
X Zhou, KY Mok, AKY Fu - Frontiers in Neuroscience, 2024 - frontiersin.org
Alzheimer's disease (AD) is a significant global health concern, with its impact amplified by
the aging population. Researchers have been working to unravel the intricate mechanisms …
the aging population. Researchers have been working to unravel the intricate mechanisms …
An Alzheimer's disease-associated common regulatory variant in PTK2B has causal effects on microglial function
E Bello, K Long, S Iwama, J Steer, S Cooper, K Alasoo… - bioRxiv, 2023 - biorxiv.org
Genome-wide association studies (GWAS) are revealing an ever-growing number of genetic
associations with disease, but identifying and functionally validating the causal variants …
associations with disease, but identifying and functionally validating the causal variants …
Addressing overlapping sample challenges in genome-wide association studies: Meta-reductive approach
F Rajabli, A Emekci - PloS one, 2024 - journals.plos.org
Polygenic risk scores (PRS) are instrumental in genetics, offering insights into an individual
level genetic risk to a range of diseases based on accumulated genetic variations. These …
level genetic risk to a range of diseases based on accumulated genetic variations. These …
Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracell signaling pathways
C Cruchaga, J Bradley, D Western, C Wang… - Research …, 2024 - researchsquare.com
Alzheimer Disease (AD) is a highly polygenic disease that presents with relatively earlier
onset (≤ 70yo; EOAD) in about 5% of cases. Around 90% of these EOAD cases remain …
onset (≤ 70yo; EOAD) in about 5% of cases. Around 90% of these EOAD cases remain …