Harnessing the potential of hydrogels for advanced therapeutic applications: Current achievements and future directions

P Lu, D Ruan, M Huang, M Tian, K Zhu… - … and Targeted Therapy, 2024 - nature.com
The applications of hydrogels have expanded significantly due to their versatile, highly
tunable properties and breakthroughs in biomaterial technologies. In this review, we cover …

Clinical applications of stem cell-derived exosomes

F Tan, X Li, Z Wang, J Li, K Shahzad… - Signal Transduction and …, 2024 - nature.com
Although stem cell-based therapy has demonstrated considerable potential to manage
certain diseases more successfully than conventional surgery, it nevertheless comes with …

Stem cell-derived exosomes: emerging therapeutic opportunities for wound healing

C Zhou, B Zhang, Y Yang, Q Jiang, T Li, J Gong… - Stem cell research & …, 2023 - Springer
Wound healing is a dynamic and highly sequential process involving a series of overlapping
spatial and temporal phases, including hemostasis, inflammation, proliferation, and tissue …

Biomaterials for in situ cell therapy

C Wang, S Wang, DD Kang, Y Dong - BMEMat, 2023 - Wiley Online Library
Cell therapy has revolutionized the treatment of various diseases, such as cancers, genetic
disorders, and autoimmune diseases. Currently, most cell therapy products rely on ex vivo …

Breakthrough of extracellular vesicles in pathogenesis, diagnosis and treatment of osteoarthritis

Z Liu, Y Zhuang, L Fang, C Yuan, X Wang… - Bioactive …, 2022 - pmc.ncbi.nlm.nih.gov
Osteoarthritis (OA) is a highly prevalent whole-joint disease that causes disability and pain
and affects a patient's quality of life. However, currently, there is a lack of effective early …

Targeted Delivery of RGD-CD146+CD271+ Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Promotes Blood–Spinal Cord Barrier Repair after …

Y Xie, Y Sun, Y Liu, J Zhao, Q Liu, J Xu, Y Qin, R He… - ACS …, 2023 - ACS Publications
Spinal cord injury (SCI) disrupts the blood–spinal cord barrier (BSCB), potentially
exacerbating nerve damage and emphasizing the criticality of preserving the BSCB integrity …

Designing drug delivery systems for cell therapy

LLW Wang, Y Gao, Z Feng, DJ Mooney… - Nature Reviews …, 2024 - nature.com
Cell therapies, such as immune cell and stem cell therapies, are being preclinically and
clinically explored for the treatment of various diseases, but are often limited by low efficacy …

Stroke: Molecular mechanisms and therapies: Update on recent developments

F Shehjar, B Maktabi, ZA Rahman, GA Bahader… - Neurochemistry …, 2023 - Elsevier
Stroke, a neurological disease, is one of the leading causes of death worldwide, resulting in
long-term disability in most survivors. Annual stroke costs in the United States alone were …

Intra-articular mesenchymal stem cell injection for knee osteoarthritis: mechanisms and clinical evidence

P Wei, R Bao - International Journal of Molecular Sciences, 2022 - mdpi.com
Knee osteoarthritis presents higher incidences than other joints, with increased prevalence
during aging. It is a progressive process and may eventually lead to disability. Mesenchymal …

Molecular mechanisms and clinical application of multipotent stem cells for spinal cord injury

M Szymoniuk, J Litak, L Sakwa, A Dryla, W Zezuliński… - Cells, 2022 - mdpi.com
Spinal Cord Injury (SCI) is a common neurological disorder with devastating psychical and
psychosocial sequelae. The majority of patients after SCI suffer from permanent disability …