From LncRNA to metastasis: The MALAT1-EMT axis in cancer progression

R Thapa, O Afzal, M Afzal, G Gupta, AA Bhat… - … -Research and Practice, 2024 - Elsevier
Cancer is a complex disease that causes abnormal genetic changes and unchecked cellular
growth. It also causes a disruption in the normal regulatory processes that leads to the …

[HTML][HTML] Recent developments in the role of protocatechuic acid in neurodegenerative disorders

R Thapa, A Goyal, G Gupta, AA Bhat, SK Singh… - EXCLI …, 2023 - ncbi.nlm.nih.gov
Neurodegenerative disorders are chronic conditions characterized by the progressive and
consistent loss of nerve cells in the brain and spinal cord. Diseases like Alzheimer's …

Exploring ncRNA-mediated regulation of EGFR signalling in glioblastoma: From mechanisms to therapeutics

R Thapa, M Afzal, A Goyal, G Gupta, AA Bhat… - Life sciences, 2024 - Elsevier
Glioblastoma (GBM) is the most prevalent and deadly primary brain tumor type, with a
discouragingly low survival rate and few effective treatments. An important function of the …

[HTML][HTML] CircRNAs: Pivotal modulators of TGF-β signalling in cancer pathogenesis

AA Bhat, G Gupta, R Dahiya, R Thapa, A Gahtori… - Non-coding RNA …, 2024 - Elsevier
The intricate molecular landscape of cancer pathogenesis continues to captivate
researchers worldwide, with Circular RNAs (circRNAs) emerging as pivotal players in the …

The role of sirtuin 1 in ageing and neurodegenerative disease: A molecular perspective

R Thapa, E Moglad, M Afzal, G Kumar, AA Bhat… - Ageing Research …, 2024 - Elsevier
Abstract Sirtuin 1 (SIRT1), an NAD+-dependent deacetylase, has emerged as a key
regulator of cellular processes linked to ageing and neurodegeneration. SIRT1 modulates …

Polyphenol-loaded nano-carriers for breast cancer therapy: a comprehensive review

AA Bhat, G Gupta, M Afzal, R Thapa, H Ali… - BioNanoScience, 2024 - Springer
Breast cancer remains a significant global health challenge, demanding innovative
therapeutic approaches. Polyphenols, a class of natural compounds widely distributed in …

Deciphering NF-kappaB pathways in smoking-related lung carcinogenesis

R Thapa, E Moglad, A Goyal, AA Bhat… - EXCLI …, 2024 - pmc.ncbi.nlm.nih.gov
One of the main causes of death worldwide is lung cancer, which is largely caused by
cigarette smoking. The crucial transcription factor NF-κB, which controls inflammatory …

Exploring ncRNA-mediated pathways in sepsis-induced pyroptosis

AA Bhat, Y Riadi, M Afzal, P Bansal, H Kaur… - … -Research and Practice, 2024 - Elsevier
Sepsis, a potentially fatal illness caused by an improper host response to infection, remains
a serious problem in the world of healthcare. In recent years, the role of ncRNA has …

Non-coding RNAs: Emerging biomarkers and therapeutic targets in ulcerative colitis

I Kazmi, ASA Altamimi, M Afzal, AA Majami… - … -Research and Practice, 2024 - Elsevier
Ulcerative colitis (UC) is a persistent inflammatory condition affecting the colon's mucosal
lining, leading to chronic bowel inflammation. Despite extensive research, the precise …

From inflammation to metastasis: The central role of miR-155 in modulating NF-κB in cancer

S Mohan, MA Hakami, HG Dailah, A Khalid… - … -Research and Practice, 2024 - Elsevier
Cancer is a multifaceted, complex disease characterized by unchecked cell growth, genetic
mutations, and dysregulated signalling pathways. These factors eventually cause evasion of …