The current monkeypox outbreaks during the COVID-19 pandemic have reignited interest in
orthopoxvirus antivirals. Monkeypox belongs to the Orthopoxvirus genus of the Poxviridae …

Retromer and sorting nexins (SNXs) transport cargoes from endosomes to the trans-Golgi
network or plasma membrane. Recent studies have unveiled the emerging roles for retromer …

Enhancing host resistance to infectious disease has received increasing attention in recent
years as a major goal of farm animal breeding programs. Combining field data with genomic …

Monkeypox virus (MPXV) is a human pathogen that is a member of the Orthopoxvirus genus,
which includes Vaccinia virus and Variola virus (the causative agent of smallpox). Human …

Poxviruses replicate in cytoplasmic structures called factories and each factory begins as a
single infecting particle. Sixty-years ago Cairns predicted that this might have effects on …

The retrograde transport inhibitor Retro-2 has a protective effect on cells and in mice against
Shiga-like toxins and ricin. Retro-2 causes toxin accumulation in early endosomes and …

During virus entry, human papillomaviruses are sorted by the cellular trafficking complex,
called retromer, into the retrograde transport pathway to traffic from the endosome to …

The advances in gene editing bring unprecedented opportunities in high throughput
functional genomics to animal research. Here we describe a genome wide CRISPR …

With over 50 million currently confirmed cases worldwide, including more than 1.3 million
deaths, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has …

Biogenesis of viral replication organelles (VROs) is critical for replication of positive-strand
RNA viruses. In this work, we demonstrate that tomato bushy stunt virus (TBSV) and the …