The acute or chronic drug treatments for different neurodegenerative and psychiatric
disorders are challenging from several aspects. The low bioavailability and limited brain …

Brain, a subtle organ of multifarious nature presents plethora of physiological, metabolic and
bio-chemical convolutions that impede the delivery of biomolecules and thereby resulting in …

Scrapie is a naturally occurring transmissible spongiform encephalopathy (TSE) or prion
disease of sheep and goats. Scrapie is a protein misfolding disease where the normal prion …

The origin of chronic wasting disease (CWD) in cervids is unclear. One hypothesis suggests
that CWD originated from scrapie in sheep. We compared the disease phenotype of sheep …

In sheep, scrapie is a fatal neurologic disease that is caused by a misfolded protein called a
prion (designated PrP Sc). The normal cellular prion protein (PrP C) is encoded by an …

Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE) that is
fatal to free-range and captive cervids. CWD has been reported in the United States …

Chronic wasting disease (CWD) is a fatal prion disease of cervids. We examined host range
of CWD by oronasally inoculating Suffolk sheep with brain homogenate from a CWD …

Prion diseases, also known as transmissible spongiform encephalopathies (TSEs), are a
group of neurodegenerative protein misfolding diseases that invariably cause death. TSEs …

Prion agents occur in strains that are encoded by the structure of the misfolded prion protein
(PrPSc). Prion strains can influence disease phenotype and the potential for interspecies …

Objective Neurofilament light chain (Nf-L) has been used to detect neuroaxonal damage in
the brain caused by physical injury or disease. The purpose of this study was to determine if …