[HTML][HTML] Spatial and temporal organization of the genome: Current state and future aims of the 4D nucleome project
The four-dimensional nucleome (4DN) consortium studies the architecture of the genome
and the nucleus in space and time. We summarize progress by the consortium and highlight …
and the nucleus in space and time. We summarize progress by the consortium and highlight …
Fluorescence in situ hybridization in plants: recent developments and future applications
J Jiang - Chromosome Research, 2019 - Springer
Fluorescence in situ hybridization (FISH) was developed more than 30 years ago and has
been the most paradigm-changing technique in cytogenetic research. FISH has been used …
been the most paradigm-changing technique in cytogenetic research. FISH has been used …
Spatial organization of chromatin domains and compartments in single chromosomes
The spatial organization of chromatin critically affects genome function. Recent chromosome-
conformation-capture studies have revealed topologically associating domains (TADs) as a …
conformation-capture studies have revealed topologically associating domains (TADs) as a …
Super-resolution imaging reveals distinct chromatin folding for different epigenetic states
Metazoan genomes are spatially organized at multiple scales, from packaging of DNA
around individual nucleosomes to segregation of whole chromosomes into distinct …
around individual nucleosomes to segregation of whole chromosomes into distinct …
Single-molecule super-resolution imaging of chromosomes and in situ haplotype visualization using Oligopaint FISH probes
Fluorescence in situ hybridization (FISH) is a powerful single-cell technique for studying
nuclear structure and organization. Here we report two advances in FISH-based imaging …
nuclear structure and organization. Here we report two advances in FISH-based imaging …
Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation
Bladder cancer is one of the most common cancers worldwide, with transitional cell
carcinoma (TCC) being the predominant form. Here we report a genomic analysis of TCC by …
carcinoma (TCC) being the predominant form. Here we report a genomic analysis of TCC by …
Versatile design and synthesis platform for visualizing genomes with Oligopaint FISH probes
BJ Beliveau, EF Joyce… - Proceedings of the …, 2012 - National Acad Sciences
A host of observations demonstrating the relationship between nuclear architecture and
processes such as gene expression have led to a number of new technologies for …
processes such as gene expression have led to a number of new technologies for …
Walking along chromosomes with super-resolution imaging, contact maps, and integrative modeling
Chromosome organization is crucial for genome function. Here, we present a method for
visualizing chromosomal DNA at super-resolution and then integrating Hi-C data to produce …
visualizing chromosomal DNA at super-resolution and then integrating Hi-C data to produce …
[HTML][HTML] The era of 3D and spatial genomics
BAM Bouwman, N Crosetto, M Bienko - Trends in genetics, 2022 - cell.com
Over a decade ago the advent of high-throughput chromosome conformation capture (Hi-C)
sparked a new era of 3D genomics. Since then the number of methods for mapping the 3D …
sparked a new era of 3D genomics. Since then the number of methods for mapping the 3D …
OligoMiner provides a rapid, flexible environment for the design of genome-scale oligonucleotide in situ hybridization probes
Oligonucleotide (oligo)-based FISH has emerged as an important tool for the study of
chromosome organization and gene expression and has been empowered by the …
chromosome organization and gene expression and has been empowered by the …