[HTML][HTML] Understanding and targeting prostate cancer cell heterogeneity and plasticity
DG Tang - Seminars in cancer biology, 2022 - Elsevier
Prostate cancer (PCa) is a prevalent malignancy that occurs primarily in old males. Prostate
tumors in different patients manifest significant inter-patient heterogeneity with respect to …
tumors in different patients manifest significant inter-patient heterogeneity with respect to …
New insights into protein kinase B/Akt signaling: role of localized Akt activation and compartment-specific target proteins for the cellular radiation response
K Szymonowicz, S Oeck, NM Malewicz, V Jendrossek - Cancers, 2018 - mdpi.com
Genetic alterations driving aberrant activation of the survival kinase Protein Kinase B (Akt)
are observed with high frequency during malignant transformation and cancer progression …
are observed with high frequency during malignant transformation and cancer progression …
MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes
MicroRNAs play important roles in regulating tumour development, progression and
metastasis. Here we show that one of the miR-200 family members, miR-141, is under …
metastasis. Here we show that one of the miR-200 family members, miR-141, is under …
Exosomes from bulk and stem cells from human prostate cancer have a differential microRNA content that contributes cooperatively over local and pre-metastatic …
CA Sánchez, EI Andahur, R Valenzuela… - …, 2015 - pmc.ncbi.nlm.nih.gov
The different prostate cancer (PCa) cell populations (bulk and cancer stem cells, CSCs)
release exosomes that contain miRNAs that could modify the local or premetastatic niche …
release exosomes that contain miRNAs that could modify the local or premetastatic niche …
A review of the pathophysiological mechanisms underlying castration-resistant prostate cancer
Androgen deprivation therapy or ADT is one of the cornerstones of management of locally
advanced or metastatic prostate cancer, alongside radiation therapy. However, despite early …
advanced or metastatic prostate cancer, alongside radiation therapy. However, despite early …
Prostate cancer stem cells: the role of androgen and estrogen receptors
E Di Zazzo, G Galasso, P Giovannelli… - …, 2015 - pmc.ncbi.nlm.nih.gov
Prostate cancer is one of the most commonly diagnosed cancers in men, and androgen
deprivation therapy still represents the primary treatment for prostate cancer patients. This …
deprivation therapy still represents the primary treatment for prostate cancer patients. This …
Role of cancer stem cells in cholangiocarcinoma and therapeutic implications
HJ Wu, PY Chu - International Journal of Molecular Sciences, 2019 - mdpi.com
Cholangiocarcinoma (CCA) is the second most common type of liver cancer, and is highly
aggressive with very poor prognosis. CCA is classified into intrahepatic cholangiocarcinoma …
aggressive with very poor prognosis. CCA is classified into intrahepatic cholangiocarcinoma …
[HTML][HTML] Reprogramming of central carbon metabolism in cancer stem cells
Cancer metabolism has been studied for years and adopted in the clinic for monitoring
disease progression and therapy response. Despite our growing knowledge of a distinctly …
disease progression and therapy response. Despite our growing knowledge of a distinctly …
Overcoming drug resistance in advanced prostate cancer by drug repurposing
Prostate cancer (PCa) is the second most common cancer in men. Common treatments
include active surveillance, surgery, or radiation. Androgen deprivation therapy and …
include active surveillance, surgery, or radiation. Androgen deprivation therapy and …
Multi-staged gene expression profiling reveals potential genes and the critical pathways in kidney cancer
Cancer is among the highly complex disease and renal cell carcinoma is the sixth-leading
cause of cancer death. In order to understand complex diseases such as cancer, diabetes …
cause of cancer death. In order to understand complex diseases such as cancer, diabetes …